{"id":137876,"date":"2023-03-06T10:50:11","date_gmt":"2023-03-06T15:50:11","guid":{"rendered":"https:\/\/cardiologynownews.org\/?p=137876"},"modified":"2023-03-06T10:50:11","modified_gmt":"2023-03-06T15:50:11","slug":"elevated-hs-ctnl-levels-precede-and-predict-pre-eclampsia","status":"publish","type":"post","link":"https:\/\/cardiologynownews.org\/?p=137876","title":{"rendered":"Elevated hs-cTnL levels precede and predict pre-eclampsia"},"content":{"rendered":"<p>Key Points:<\/p>\n<ul>\n<li>There have been limited data regarding the biomarkers that may predict the development and severity of preeclampsia.<\/li>\n<li>hs-cTnI was significantly elevated in pregnant women who would later develop preeclampsia starting at 14 weeks. A cutoff hs-cTnI value of &gt;2.2pg\/ml at 14 weeks and &gt;2.6pg\/ml at 26 weeks had a combined 100% negative predictive value for predicting severe preeclampsia in women at high a prior risk.<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>Pre-eclampsia complicates up to 8% of pregnancies, but there have been limited data on biomarkers which can predict onset and disease severity. In a breaking presentation at the 2023 ACC Conference today, <a href=\"https:\/\/esc365.escardio.org\/person\/3849\">Dr. Dirk Westermann<\/a> (University Heart Center Freiburg) and his team presented their study: \u201cPrediction of Preeclampsia using High-Sensitivity Troponin I.\u201d<\/p>\n<p>This study was a multi-center observational study comprising four international cohorts of pregnant women (SCOPE, MAViS, PRINCE, and OCC) which evaluated the association of high-sensitivity troponin with pre-eclampsia onset and severity. The Abbott high-sensitivity troponin assay (hs-cTnI) was used. The preeclampsia definition varied based on cohort (PRINCE utilizing GSGO guidelines, MAViS and SCOPE utilizing ISSHP, and OCC utilizing DSOG). Severe preeclampsia was defined as preeclampsia requiring delivery &lt;34 weeks gestation; high preeclampsia risk was defined as anyone meeting NICE guidelines for prophylactic aspirin.<\/p>\n<p>A total of 2293 pregnant women were identified. Of those 7.8% of women developed preeclampsia, and 0.9% had severe preeclampsia. 17.3% of women were identified as high-risk a priori. The average age was 32, and there was a higher prevalence of African American ancestry, hypertension, diabetes, and history of multiple pregnancies in women who developed preeclampsia. hs-cTnI\u00a0 was persistently elevated starting at 14 weeks (and up to 29 weeks) of gestational age in the women who ultimately developed preeclampsia (all p&lt;0.001). A cutoff hs-cTnI value of &gt;2.2pg\/ml at 14 weeks and &gt;2.6pg\/ml at 26 weeks had a combined 100% negative predictive value for predicting severe preeclampsia in women at high a prior risk (ie, meeting NICE criteria). \u00a0A cutoff hs-cTnI value of &gt;1.8pg\/ml at 14 weeks and &gt;1.9pg\/ml at 26 weeks predicted the presence of any preeclampsia.<\/p>\n<p>When discussing the clinical implications of the study at ACC, Dr. Westermann stated: \u201cElevated levels of hs-cTnI may precede the development of preeclampsia\u2026.and may also have considerable potential in grading preeclampsia risk [and severity] in pregnant women\u2026a randomized, prospective trial needs to assess the potential benefits.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Points: There have been limited data regarding the biomarkers that may predict the development and severity of preeclampsia. hs-cTnI was significantly elevated in pregnant women who would later develop preeclampsia starting at 14 weeks. A cutoff hs-cTnI value of &gt;2.2pg\/ml at 14 weeks and &gt;2.6pg\/ml at 26 weeks had a combined 100% negative predictive [&hellip;]<\/p>\n","protected":false},"author":40603,"featured_media":137877,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[878,8],"tags":[877,45,47,185],"ppma_author":[1029],"class_list":{"0":"post-137876","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-acc-2023","8":"category-news","9":"tag-acc-2023","10":"tag-conference","11":"tag-featured","12":"tag-news","13":"author-leah-kosyakovsky"},"authors":[{"term_id":1029,"user_id":40603,"is_guest":0,"slug":"leah-kosyakovsky","display_name":"Leah Kosyakovsky","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/864bde69f6f1f80e91e4a97f0a0ba8daa64c2bb702be09ed787444c7dfa045bb?s=96&r=g","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/137876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/users\/40603"}],"replies":[{"embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=137876"}],"version-history":[{"count":1,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/137876\/revisions"}],"predecessor-version":[{"id":137878,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/137876\/revisions\/137878"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/media\/137877"}],"wp:attachment":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=137876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=137876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=137876"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fppma_author&post=137876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}