Maria Trinidad Soria-Florido et al. published the results of their study on high-density lipoprotein (HDL) function and coronary syndrome in Circulation. They showed that low amount of HDL sphingosine-1-phosphate (S1P) and apolipoprotein A-I and low cholesterol efflux capacity are associated with cardiovascular manifestations of angina. HDL function was studied by measuring cholesterol efflux capacity, S1P, and ApoA-I in apolipoprotein B-depleted plasma and they showed that impaired cholesterol function is associated with a higher risk of acute coronary syndrome (ACS), irrespective of HDL cholesterol (HDL-C) concentrations.<\/p>\n
The investigators selected a subgroup of patients who were participating in PREDIMED study, which was a randomized clinical trial including patients with high cardiovascular risk factors to evaluate the effects of following a traditional Mediterranean Diet (TMD) on the primary prevention of cardiovascular outcomes. The primary endpoints were decided to be fatal or non-fatal myocardial infarction and\/or fatal or non-fatal unstable angina. The committee responsible to adjudicate the events was blinded to the treatment. Dr. Trinidad et. al. implemented a nested 1:2 case-control design, matching two controls by age (\u00b15 years), sex, body mass index, intervention group, and time-to-event. They obtained apolipoprotein B-depleted plasma samples and measured the HDL related activity in the sample.<\/p>\n
The findings showed that except for plasma HDL-C concentrations and the levels of ApoA-I in HDL, all other HDL related biomarkers correlated weakly with each other. There was an almost linear correlation between all HDL related biomarkers (except for ApoA-IV) and the incidence of cardiovascular events. They also showed that there is a strong relationship between low cholesterol efflux capacity (CEC) and a higher incidence of myocardial infarction.<\/p>\n
Previous studies have shown that there is an association between low CEC and ACS in hypertriglyceridemia patients, but Maria Trinidad Soria-Florido et al. showed that this association also exists in patients with normal triglyceride levels. Hypertriglyceridemia probably exaggerates the effect. They also showed that not only HDL-bound S1P can predict atherosclerotic lesions development and its extent, but also S1P levels in apolipoprotein B-depleted plasma is associated inversely with ACS risk.<\/p>\n
The study was limited by the small sample size and lack of thorough evaluation of the HDL oxidative-inflammatory index.<\/p>\n","protected":false},"excerpt":{"rendered":"
Maria Trinidad Soria-Florido et al. published the results of their study on high-density lipoprotein (HDL) function and coronary syndrome in Circulation. They showed that low amount of HDL sphingosine-1-phosphate (S1P) and apolipoprotein A-I and low cholesterol efflux capacity are associated with cardiovascular manifestations of angina. HDL function was studied by measuring cholesterol efflux capacity, S1P, […]<\/p>\n","protected":false},"author":219,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"footnotes":""},"categories":[1],"tags":[],"ppma_author":[1051],"class_list":{"0":"post-9146","1":"post","2":"type-post","3":"status-publish","4":"format-aside","6":"category-uncategorized","7":"post_format-post-format-aside","8":"author-mahshid"},"authors":[{"term_id":1051,"user_id":219,"is_guest":0,"slug":"mahshid","display_name":"Mahshid Mir","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/43b34884ba0eb53ed116aa56414d4ea88c4b5cc05bf1a666bdb9ed92c55bdaf3?s=96&r=g","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/9146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/users\/219"}],"replies":[{"embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9146"}],"version-history":[{"count":7,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/9146\/revisions"}],"predecessor-version":[{"id":9219,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=\/wp\/v2\/posts\/9146\/revisions\/9219"}],"wp:attachment":[{"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9146"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/cardiologynownews.org\/index.php?rest_route=%2Fwp%2Fv2%2Fppma_author&post=9146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}