Aditya Ganti, M.D.
Contemporary Trends in the Use of Ticagrelor in ACS Patients National Cardiovascular Data Registry
According to a recent registry study published in JAHA, there is an increase in the use of ticagrelor in hospital and at discharge, with simultaneous decrease in the use of clopidogrel and prasugrel, in patients with acute myocardial infarction (AMI).
CTA Verified High Risk Coronary Plaque Predicts ACS ICONIC TRIAL
Coronary computed tomography angiography (CTA)-guided vulnerable plaque characteristics have predictive value for future acute coronary syndrome (ACS) in high-risk patients according to Incident COronary EveNts Identified by Computed Tomography (ICONIC) trial which is published in the Journal of the American College of Cardiology.
Renal Denervation Is Promising for Resistant Hypertension in a Sham Controlled Trial SPYRAL HTN-ON MED Study
A recent study published on The LANCET demonstrated that renal denervation, targeting the sympathetic nervous system, significantly reduced systolic blood pressure among patients with uncontrolled hypertension who were taking antihypertensive medications.
Discharging Patients Is Safe, the Next Day After Minimalist TAVR
In a recent study published in the Journal of the American College of Cardiology (JACC), it was found that patients undergoing uncomplicated TAVR have a safe next-day discharge (NDD) profile with no difference in 30-day mortality rate in comparison to an increased length of hospital stay. In addition, the study also highlighted better 1-year clinical outcomes in patients as compared to non-NDD group. Continue reading
Assessment of Long-term Outcomes in Patients Undergoing SAVR
A contemporary cohort study recently published in Journal of the American College of Cardiology highlighted the clinical significance of age and other associated comorbidities in determining the clinical outcome in patients undergoing surgical aortic valve replacement (SAVR). The 10-year mortality rate was found to be considerably high in elderly SAVR recipients of a bioprosthetic valve and almost one-third of the population exhibited subclinical structural valve degeneration (SVD). Continue reading
SWAP 4 trial: De-escalation of P2Y12 Inhibitors
In a recent article published in The Circulation, it has been found that the use of a loading dose while switching between P2Y12 inhibitors in patients with coronary artery disease is associated with mitigation of the reactivity of platelets. The study has also emphasized that timing of administration of loading dose has no impact on platelet reactivity.
Febuxostat Non-Inferior to Allopurinol in Reduction of MACE but Increases Mortality
In a recent article, published in The New England Journal of Medicine, the rates of major cardiovascular events with febuxosat were similar to allopurinol in patients with gout and concomitant cardiovascular disease. However, the mortality rates either due to cardiovascular deaths or any other cause were higher with febuxostat than allopurinol. Continue reading
CABG Versus PCI in Multivessel Disease
In a recent study published in The Lancet, it was found that there is a mortality benefit for patients with multivessel disease undergoing CABG compared to PCI. However, the reduction in mortality was not statistically significant in patients with only left main artery disease. With recent advancements in stenting techniques, the benefit of using CABG over PCI has been debatable. Prior to this , no study was powered to compare the mortality benefits between these interventions.