Smartphone App May Improve Medication Adherence in Hypertension

A new study published in the Journal of American Medical Association finds that use of a smartphone app can result in a small, but significant improvement in self-reported medication adherence, although it does not affect blood pressure control in patients with hypertension.

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Prevention of Cardiovascular Events in PAD and the Role of Anticoagulation

Dr. Sonia Anand Speaks at Brigham and Women’s Hospital

EAGLES- A Randomized Clinical Trial Showing No Evidence of Smoking Cessation Treatments Association with MACE

EAGLES (Evaluating Adverse Events in a Global Smoking Cessation Study), a randomized clinical trial, published in the Journal of the American Medical Association, provides evidence that smoking cessation medications do not increase the risk of serious cardiovascular events in the general population of smokers. Continue reading

Preventing Heart Attack, Stroke, and Major Adverse Limb Events in Patients with Stable Atherosclerotic Vascular Disease

Dr. John Eikelboom Speaks at Brigham and Women’s Hospital

Preventing Heart Attack, Stroke, and Major Adverse Limb Events in Patients with Stable Atherosclerotic Vascular Disease Dr. John Eikelboom Speaks at Brigham and Women's Hospital

Predictors of Device Related Thrombosis After Transcatheter Left Atrial Appendage Occlusion

In a recent study published in Circulation: Cardiovascular Interventions, Pracon et al. suggested that the incidence of device related thrombosis (DRT) among patients undergoing percutaneous left atrial appendage occlusion is related to patient  (history of thromboembolic events and lower left ventricular ejection fraction) and procedural (deep implantation and larger occluder size) characteristics.

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Association of High-Sensitivity Cardiac Troponins (hs-cTn) and the Risk of New-onset Heart Failure

A recent study, published in the Journal of American College of Cardiology, concluded that there is a strong association of high sensitivity cardiac troponin (hs-cTn) with the risk of new-onset heart failure (HF), independent of population at risk, cardiovascular risk factors, and natriuretic peptide levels. Continue reading

Role of Cholesterol Screening and Statin Therapy in Hypercholesterolemia

A nationally representative, cross-sectional study published in Circulation highlighted the importance of cholesterol screening and statin prescription in patients with familial hypercholesterolemia (FH) and other forms of severe dyslipidemia. It was found that despite the high prevalence of cholesterol screening and awareness, only ≈50% of adults with FH are on statin therapy, with even fewer prescribed a high-intensity statin. Continue reading

Febuxostat Non-Inferior to Allopurinol in Reduction of MACE but Increases Mortality

In a recent article, published in The New England Journal of Medicine, the rates of major cardiovascular events with febuxosat were similar to allopurinol in patients with gout and concomitant cardiovascular disease. However, the mortality rates either due to cardiovascular deaths or any other cause were higher with febuxostat than allopurinol. Continue reading

Intervention in Barbershops Improved Blood Pressure Control

The results of a cluster-randomized trial conducted in black barbershops have been published in the New England Journal of Medicine and were presented by Dr Ronald G. Victor from Los Angeles, California at the ACC 2018 Conference in Orlando. The study showed that health promotion by barbers along with medication management in barbershops by pharmacists, resulted in a larger blood pressure reduction in black male barbershop patrons with uncontrolled hypertension as compared to lifestyle modifications and doctor appointments.

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Is Sodium Bicarbonate or N-Acetyl-Cysteine Effective in Preventing Contrast-Induced Nephropathy?

In a recent study published in the New England Journal of Medicine, it was found that amongst patients undergoing angiography, sodium bicarbonate is not better than sodium chloride  and neither is acetylcysteine better than oral placebo in the prevention of a composite outcome of death, need for dialysis, or persistent kidney injury. The treatment was also ineffective in reducing the risk of contrast-associated acute kidney injury.

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CANTOS subanalysis: Effect of Canakinumab on New Onset Diabetes in Pre-Diabetic Patients

Dr. Everett and Dr. Gibson Discuss

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CANTOS subanalysis: Effect of Canakinumab on New Onset Diabetes in Pre-Diabetic Patients Dr. Everett and Dr. Gibson Discuss

Does Magnitude of CRP Level Reduction Correlate With Cardiovascular Mortality?

In a recent study published in The Lancet, it has been found that the magnitude of reduction in C Reactive Protein (CRP) levels due to treatment with Canakinumab, an interleukin 1β targeting monoclonal antibody, may directly correlate with a decrease in major cardiovascular events in post-myocardial infarction (MI) patients, even in the absence of an alteration in LDL levels. Continue reading

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

In a recent retrospective cohort study published in the New England Journal Medicine, a significant association was found between acute respiratory infections, particularly influenza, and the occurrence of acute myocardial infarction (MI) in the following week. The study also highlights the increased risk in older patients and in those who are hospitalized for the first time for an MI. Continue reading

S-LAAO Reduces Thromboembolism in AFib Patients After Heart Surgery

In a recent retrospective cohort study published in the Journal of American Medical Association conducted on patients with atrial fibrillation (AF) undergoing cardiac surgery, surgical left atrial appendage occlusion (S-LAAO) as compared with no surgical left atrial appendage occlusion (no S-LAAO) was significantly associated with lower risk of readmission for thromboembolism.  Continue reading

D-dimer Level is Associated With Increased Long-term Cancer Incidence and All-cause Mortality

According to a recently published article in Circulation, it was found that D-dimer level is an independent predictor of the long-term (up to 16 years) risk of arterial and venous events, cause-specific mortality, and the incidence of new cancers. The results of the study are based on a  subanalysis of the LIPID trial. Continue reading

Does Marijuana Use Impact Cardiovascular Health?

With the increasing use and the legalization of marijuana in several states of USA, there is a need to evaluate its impact on the health. To explore this, a systematic review was recently published in Annals of Internal Medicine by Ravi et al. In the study, the investigators studied the association between marijuana use and cardiovascular outcomes. The authors concluded, “Evidence examining the effect of marijuana on cardiovascular risk factors and outcomes, including stroke and myocardial infarction, is insufficient”. Continue reading

Novel Echo Markers In Stroke Risk Stratification In AFib

The assessment of left atrial reservoir strain and P-wave to A’ duration on tissue Doppler imaging provides additional risk stratification for stroke after initial CHA2DS2-VASc scoring, according to a study published in the European Heart Journal, and may prove helpful in guiding decisions about anticoagulation for patients after the diagnosis of atrial fibrillation. Continue reading