PolyIran Trial: Polypill Prevents Cardiovascular Events PolyIran Trial: Fixed-Dose Combination Therapy With Aspirin, a Statin and Two Anti-hypertensives Reduced Cardiovascular Events As Compared to Non-Pharmacological Intervention

A four-component polypill, including aspirin, atorvastatin, hydrochlorothiazide, and enalapril or valsartan, effectively reduced major cardiovascular events in a real-life setting study. The results of the PolyIran trial by Roshandel G. et al. was published in Lancet.

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Population Based Cohort Study: With or Without AFib, CHA₂DS₂-VASc Score is a Sensitive Predictor and Stratifies the Risk of MACCE 22,000 Patient Study Showed Increased Risk of Ischemic Stroke and New-Onset Atrial Fibrillation in Patients Without Atrial Fibrillation

Giulia Renda et al. recently published in the European Journal of Preventive Cardiology that the CHA2DS2-VASc score is a sensitive measure of predicting new-onset atrial fibrillation (AF) and adverse outcomes in patients with and without atrial fibrillation in the middle-aged patient population. Continue reading

CLIMA Registry: OCT-Defined Plaque Morphology Links to Major Coronary Events CLIMA Registry: Presence of Multiple High Risk Plaque Features Detected By Optical Coherence Tomography Associated With Increased Risk of Cardiovascular Events

Data from CLIMA registry shows that simultaneous presence of four optical coherence tomography (OCT) plaque vulnerability features are associated with a seven-fold increased risk of future major coronary events. The study, led by Prati et al., is recently published in the European Heart Journal.

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International Ongoing Study Finds Low Prevalence of PE in Patients Presenting to the ER with First Time Syncopal Episode Study Demonstrates Low Incidence of Pulmonary Embolism In Patients Presenting with Syncope to The Emergency Department

In an ongoing diagnostic multicentric prospective study being conducted to evaluate and improve the management of patients in the emergency room (ER) presenting with syncope, an analysis was done to look for the prevalence of pulmonary embolism (PE). Results of the analysis performed by Patrick Badertscher et al were recently published in JACC  and it was found that PE was uncommon in patients admitted to the ER and hence does not need screening in patients presenting with syncope. Continue reading

New Study Shows Elevated Levels of Troponin After Exercise Associated with Increased Rate of Cardiovascular Events

A study led by Dr. Vincent Aengevaeren, published in Circulation, showed that an elevated exercise-induced troponin I was associated with an increased risk of mortality and cardiovascular events in older long-distance workers. This may suggest that exercise-induced troponin elevations could be a marker of a future cardiovascular event and not a physiological response to exercise.

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Novel Physiology-Based Method of Estimating Myocardial Ischemic Burden

Murai et al. devised a novel physiology-based method of estimating the amount of myocardium subtended by coronary stenosis, which is feasible and can be performed in the catheterization laboratory with a Doppler sensor-equipped guidewire. The study was published in the recent issue of Circulation: Cardiovascular Interventions.

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11,000 Patient Study Demonstrates That Higher 24 hour and Nighttime Blood Pressure Readings Associated With Increased Risk of Cardiac Events

In an original investigation done by Dr.Wen-Yi Yang and his team, the results of which got published in JAMA, concluded that raised 24-hour and nighttime blood pressure (BP) readings are linked to increased risk of death and composite cardiovascular outcomes significantly. They considered it to be an optimal way of measuring risk but noted the difference was small for the improvement in the model.

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Biologic Therapy for Psoriasis Associated with Reduced Coronary Inflammation

Anti-inflammatory biologic therapy used for the treatment of moderate to severe psoriasis is associated with reduced coronary inflammation in patients with the skin condition. The recent study by Elnabawi et al., published in the Journal of the American Medical Association (JAMA) Cardiology, revealed.
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Study Shows Preoperative Fractional Flow Reserve Associated with 6-Month Anastomotic Graft Functionality in Patients Undergoing Coronary Artery Bypass Graft IMPAG trial

A team led by Dr David Glineur working in Canada and Europe on the IMpact of Preoperative fractional flow reserve on Arterial bypass Graft anastomotic function(IMPAG) trial published in European Heart Journal  that  fractional flow reserve(FFR) measured  before surgical revascularization and anastomotic function are significantly related to each other at 6 months with a cut-off value of 0.78. They also found that measuring FFR before Coronary Artery Bypass Grafting(CABG)surgery had improved function of the anastomotic graft.

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