Novel siRNA targeting therapy lepodisiran results in a dose-dependent and sustained reduction in Lipoprotein(a)
Key Points: There are currently no approved targeted therapies for the reduction…
ARIES-HM3: Aspirin avoidance Is safe and reduces bleeding events in patients with HM3 LVAD on VKA
Key Points: Since the advent of novel HeartMate 3 LVAD technology with…
POCKET-COST-HF: Comprehensive Cost Disclosure improves cost-informed decision making
Key Points: Out-of-pocket costs for GDMT in HFrEF have risen substantially with…
Dietary sodium reduction significantly lowered BP in middle-aged to elderly adults
Key Points: Daily sodium intake remains high (on average ~3,500 mg/day), despite…
TEAMMATE Trial: Everolimus with Low-Dose Tacrolimus to Prevent Rejection in Children after Cardiac Transplantation
Key Points This was the first randomized trial to evaluate the safety…
Percutaneous Coronary Intervention Improved Symptoms in Stable Angina: ORBITA-2 trial
Key points: PCI is often performed for chronic stable angina, but current…
Lowering blood pressure significantly reduced dementia risk in people with hypertension in rural China
Key Points: Intensive blood pressure (BP) lowering intervention was tested on hypertensive…
MINT Trial – In Patients with MI and Anemia, Liberal Blood Transfusion not Significantly Different to Restrictive Strategy in Reducing Death or MI
Key Points Anemia is common among individuals with acute myocardial infarction, however,…
DAPA-MI: Dapagliflozin improves clinical and cardiometabolic outcomes in post-AMI patients with impaired LV function versus placebo
Key Points This trial of patients with acute myocardial infarction (AMI) and…
SELECT TRIAL: Semaglutide reduces cardiovascular events among overweight or obese patients with cardiovascular disease in the absence of diabetes
Key Points: Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, has previously been shown…
ARAMIS: Anakinra is safe but does not reduce complications of acute myocarditis
Key Points: While myocarditis is an inflammatory condition, there have not yet…
PUSH-AHF: Natriuresis-guided diuresis approach increases natriuresis and diuresis without improving all-cause mortality or HF hospitalization
Key Points: Diuretic requirement Is a major contributor to hospital length-of-stay for…
SGLT2 inhibitors not linked with improved survival in hospitalized COVID-19 patients
Key Points: In hospitalized COVID-19 patients, treatments targeting the virus’s pathobiology (e.g.…
Inorganic nitrate improves safety of coronary angiography in patients at kidney injury risk
Key Points: Contrast-induced nephropathy (CIN) is a clinical condition that refers a…
Atrial Fibrillation ablation improves outcomes in patients with end-stage HF
Key Points Evidence suggests that catheter ablation for atrial fibrillation (AF) is…
DICTATE-AHF Trial: Early Dapagliflozin in AHF does not meet primary endpoint of diuretic efficiency
Key Points: The DICTATE-AHF trial explored early initiation of the SGLT2 inhibitor…
DANPACE II: Minimizing atrial pacing in sinus node dysfunction leads to increased syncope with no difference in development of AF
Key Points This trial randomizing patients with an indication for initial dual…
RIGHT Trial: Anticoagulation shows no benefit after primary PCI in STEMI
Key Points: The RIGHT trial assessed the benefit of post-procedural anticoagulation (PPA)…
OPT-BIRISK: Extended P2Y12 Monotherapy is Superior to Extended DAPT for High Risk ACS Patients
Key Points This trial randomizing patients at high bleeding and/or ischemic risk…
OCTIVUS: OCT- Guided PCI is non-inferior to IVUS-Guided PCI for Clinical Outcomes
Key Points This pragmatic trial randomizing patients to optical coherence tomography (OCT)-guided…