First-in-human Trial of CRISPR Gene-editing ANGPTL3 Safely Lowered Cholesterol and Triglycerides
Key Points: CTX310 is a first-in-class in vivo CRISPR-Cas9 therapy designed to…
Providing Healthy Food + Nutrition Counseling Improved Quality of Life in HF Patients: FOOD-HF Trial
Key Points: The FOOD‑HF Trial was a single center randomized trial that…
Tirzepatide Lowers MACE vs Dulaglutide in SURPASS-CVOT Patients With Heart Failure
Key Points In SURPASS-CVOT, tirzepatide was previously shown to be non-inferior to…
PCSK9-inhibitors Do Not Reduce Early Cardiac Allograft Vasculopathy: The CAVIAR Trial
Key Points The CAVIAR trial enrolled recent heart transplant recipients to receive…
DAPT-MVD: Extended DAPT reduces MACCE in patients with multi-vessel disease after DES
Key Points: The optimal duration and choice of dual antiplatelet therapy (DAPT)…
NOAC Monotherapy Non-Inferior to Combination Therapy for Net Adverse Clinical events in AF Patients Post–DES: ADAPT AF-DES Trial
Key Points The ADAPT AF-DES randomized trial compared NOAC monotherapy (apixaban or…
Prasugrel Might be a Better Choice than Ticagrelor For DAPT after PCI for Patients with Diabetes and MVD: The TUXEDO-2 Trial
Key Points TUXEDO-2 directly compared ticagrelor vs prasugrel based DAPT in 1,800…
POLY-HF: Polypill for HFrEF Shows Promise in Reducing Medication Burden Among Underserved Patients
Key Points: Patients with heart failure with reduced ejection fraction (HFrEF) often…
CorCMR: Stress Cardiac MRI Uncovers Hidden Angina and Improves Quality of Life in Patients Without Obstructive Coronary Disease
Key Points: Stress cardiac MRI (CMR) enhanced diagnostic accuracy for patients with…
CELEBRATE: Early Pre-hospital Subcutaneous Zalunfiban Improves Coronary Patency and Outcomes in STEMI Without Increasing Severe Bleeding
Key Points: Early pre-hospital administration of subcutaneous zalunfiban improved coronary patency and…
Family-Based Intervention Reduced Blood Pressure in Adults in Rural China: The Healthy Family Program
Key Points: A community- and family-based intervention can reduce systolic blood pressure…
DASH Diet Patterned Groceries Help Reduce Blood Pressure in Black Adults: The GOFRESH Trial
Key Points: The GOFRESH trial, a parallel-group randomized study, was conducted to…
BETTER-BP: Offering Cash Incentives Improves Anti-Hypertensive Medication Adherence, But Not Blood Pressure Control
Key Points: Adherence to antihypertensive medications remains a persistent challenge in clinical…
FAVOR IV-QVAS: Angio-FFR–Guided CABG During Valve Surgery Improves Outcomes
Key Points: The FAVOR IV-QVAS trial tested the hypothesis physiology-guided coronary artery…
ABLATION Trial – Biatrial Ablation During Mitral Valve Surgery Better than LA Ablation Alone
Key Points: Persistent atrial fibrillation (AF) is common among patients with rheumatic…
Oral KCl Supplementation Lowers Sodium Load and Blood Pressure in Hypertension: SSTT Trial
Key Points The See Sodium to Treat (SSTT) Trial tested whether isolated…
Daily Coffee Lowers AFib Recurrence After Cardioversion: The DECAF Trial
Key Points The Does Eliminating Coffee Avoid Fibrillation (DECAF) trial is the…
A Liberal Transfusion Strategy Does Not Significantly Reduce MACE vs a Restrictive Strategy in High Cardiac Risk Patients: The TOP Trial
Key Points: In patients at high cardiac risk undergoing major vascular or…
Two Factor XI Antibodies For the Prevention of Post- operative VTE: Results from ROXI-VTE-I and ROXI-VTE-II Trials
Key Points: ROXI-VTE-I and ROXI-VTE-II evaluated two distinct factor XI monoclonal antibodies…
Early Surgery Provides Durable Survival Advantage in Asymptomatic Severe Aortic Stenosis: Final 10-Year Outcomes from the RECOVERY Trial
Key Points: Over a decade of follow-up, early surgical aortic valve replacement…