ARAMIS: Anakinra is safe but does not reduce complications of acute myocarditis
Key Points: While myocarditis is an inflammatory condition, there have not yet…
PUSH-AHF: Natriuresis-guided diuresis approach increases natriuresis and diuresis without improving all-cause mortality or HF hospitalization
Key Points: Diuretic requirement Is a major contributor to hospital length-of-stay for…
SGLT2 inhibitors not linked with improved survival in hospitalized COVID-19 patients
Key Points: In hospitalized COVID-19 patients, treatments targeting the virus’s pathobiology (e.g.…
Inorganic nitrate improves safety of coronary angiography in patients at kidney injury risk
Key Points: Contrast-induced nephropathy (CIN) is a clinical condition that refers a…
Atrial Fibrillation ablation improves outcomes in patients with end-stage HF
Key Points Evidence suggests that catheter ablation for atrial fibrillation (AF) is…
DICTATE-AHF Trial: Early Dapagliflozin in AHF does not meet primary endpoint of diuretic efficiency
Key Points: The DICTATE-AHF trial explored early initiation of the SGLT2 inhibitor…
DANPACE II: Minimizing atrial pacing in sinus node dysfunction leads to increased syncope with no difference in development of AF
Key Points This trial randomizing patients with an indication for initial dual…
RIGHT Trial: Anticoagulation shows no benefit after primary PCI in STEMI
Key Points: The RIGHT trial assessed the benefit of post-procedural anticoagulation (PPA)…
OPT-BIRISK: Extended P2Y12 Monotherapy is Superior to Extended DAPT for High Risk ACS Patients
Key Points This trial randomizing patients at high bleeding and/or ischemic risk…
OCTIVUS: OCT- Guided PCI is non-inferior to IVUS-Guided PCI for Clinical Outcomes
Key Points This pragmatic trial randomizing patients to optical coherence tomography (OCT)-guided…
Metanalysis: OCT or IVUS is associated with improved outcomes compared to angiography alone
Key Points This metanalysis integrating data from ILUMIEN IV and OCTOBER Trials…
Addressing the Triple Threat: Proactive Screening Resulted in Improved Early Detection of Coronary Artery Disease, Atrial Fibrillation, and Heart Failure in the RED-CVD Trial
Key Points: Tertiary screening for chronic cardiovascular disease as a means to…
OCTOBER Trial: OCT Reduces MACE in complex bifurcation lesions
Key Points This trial randomizing patients with stable angina, unstable angina (UA),…
ONCO-DVT– 1 Year of Anticoagulation With Edoxaban Is Superior To 3-Months In Cancer Patients With Distal DVT
Key Points: The optimal duration of therapy for distal deep vein thrombosis…
ILUMIEN IV: OCT-guided complex PCI led to increased minimal stent area, improved safety, and lower in-stent thrombosis rates but no difference in target vessel failure at 2 years
Key Points This trial randomizing patients with diabetes and/or complex lesions to…
MULTISTARS AMI Trial: Immediate Complete Multivessel PCI non-inferior to staged approach in patients with STEMI and MVD
Key Points: It is well known that patients with STEMI often have…
FRAIL-AF: Switching to NOACs in Frail Elderly with AF Linked to Increased Bleeding
Key Points: The FRAIL-AF trial is an open-label, randomized controlled trial that…
ARREST: Transfer to a cardiac arrest center instead of the nearest ED does not improve mortality in OHCA patients
Key Points: Sudden cardiac death causes a fifth of all deaths in…
ATTRibute-CM: Acoramidis Linked to Improved clinical outcomes in transthyretin amyloid cardiomyopathy
Key Points: Transthyretin amyloid cardiomyopathy develops because of mis-folded proteins infiltrating the…
The ADVENT of Pulsed Field Ablation for Atrial Fibrillation: just as effective and safe as traditional thermal ablation, but faster
Key Points: ADVENT was the first randomized controlled trial comparing pulsed field…