ATTRibute-CM Open-Label Extension: Acoramidis for ATTR-CM Provides Sustained Reductions in Mortality Through 54 months
Key Points: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive disease caused by destabilization of the transthyretin (TTR) protein, which misfolds... Read more.
Dig-RHD: Digoxin Reduces Heart Failure Events in Patients with Rheumatic Heart Disease
Key Points: Rheumatic heart disease (RHD) results from heart valve damage caused by rheumatic fever due to streptococcal pharyngitis that typically occurs in childhood.... Read more.
TRISCEND II Two-Year Follow-Up: Transcatheter Tricuspid Valve Replacement Demonstrates Durable TR Elimination and Quality-of-Life Improvement at Two Years
Key Points: Severe tricuspid regurgitation is common and is associated with reduced quality of life, recurrent heart failure hospitalizations, and increased mortality.... Read more.
SURVIV: Transcatheter Mitral Valve-in-Valve Is Superior to Redo Surgery for Failed Mitral Bioprostheses at 1 Year
Key Points: The use of bioprosthetic mitral valve replacement has increased substantially over the past two decades. Because bioprosthetic valves deteriorate over... Read more.
MOMENTUM: Hypercortisolism Highly Prevalent Among Patients With Resistant Hypertension
Key Points: Resistant hypertension (rHTN), defined as blood pressure remaining above goal despite use of three or more antihypertensive medication classes including... Read more.
HOST-EXAM 10-Year Follow-Up: Clopidogrel Monotherapy Associated With Lower Rate of Primary Composite Endpoint vs Aspirin After PCI
Key Points: Antiplatelet monotherapy is a cornerstone of secondary prevention after PCI and is generally continued indefinitely after completion of DAPT. Aspirin... Read more.
GPS-CAD: A Coronary Artery Calcium Score of Zero Cannot Reliably Exclude Atherosclerotic Plaque Across Diverse Global Populations
Key Points: Coronary artery calcium scoring (CACS) is a widely used, non-invasive screening tool for atherosclerotic coronary artery disease (ACAD). A CAC score... Read more.
RECOVER-Autonomic: Ivabradine Alone Did Not Improve Orthostatic Intolerance in Post-COVID POTS, But May Have Additional Benefit
Key Points: Postural orthostatic tachycardia syndrome (POTS) is a complex, multisystem disorder characterized by orthostatic intolerance and excessive tachycardia... Read more.
SPIRIT-HF Trial: No Significant Benefit of Spironolactone in HFpEF or HFmrEF, With Possible Signal of Harm
Key Points: Heart failure with preserved ejection fraction (HFpEF) and heart failure with mildly reduced ejection fraction (HFmrEF) contribute substantially to the... Read more.
DAPT-MVD: Extended DAPT reduces MACCE in patients with multi-vessel disease after DES
Key Points: The optimal duration and choice of dual antiplatelet therapy (DAPT) after one year for patients with multivessel disease who undergo percutaneous coronary... Read more.