Ultrasound-Facilitated Catheter-Directed Fibrinolysis Reduces Early Clinical Deterioration in Intermediate-Risk Pulmonary Embolism: HI-PEITHO Trial
Key Points Acute pulmonary embolism (PE) remains a leading cause of cardiovascular morbidity and mortality, particularly in patients with intermediate-risk disease... Read more.
CorCMR: Stress Cardiac MRI Uncovers Hidden Angina and Improves Quality of Life in Patients Without Obstructive Coronary Disease
Key Points: Stress cardiac MRI (CMR) enhanced diagnostic accuracy for patients with angina but no obstructive coronary artery disease, identifying microvascular... Read more.
CELEBRATE: Early Pre-hospital Subcutaneous Zalunfiban Improves Coronary Patency and Outcomes in STEMI Without Increasing Severe Bleeding
Key Points: Early pre-hospital administration of subcutaneous zalunfiban improved coronary patency and reduced composite adverse outcomes at 30 days in patients... Read more.
FAVOR IV-QVAS: Angio-FFR–Guided CABG During Valve Surgery Improves Outcomes
Key Points: The FAVOR IV-QVAS trial tested the hypothesis physiology-guided coronary artery bypass grafting (CABG) using angiography-derived fractional flow reserve... Read more.
Early Surgery Provides Durable Survival Advantage in Asymptomatic Severe Aortic Stenosis: Final 10-Year Outcomes from the RECOVERY Trial
Key Points: Over a decade of follow-up, early surgical aortic valve replacement (AVR) continued to confer a substantial survival advantage over conservative management... Read more.
CLOSURE-AF: Left Atrial Appendage Closure Fails to Achieve Noninferiority to Medical Therapy in AF Patients With High Bleeding Risk
Key Points: The CLOSURE AF study compared catheter-based left atrial appendage closure with physician-directed standard medical care (including timely anticoagulant... Read more.
Biomarkers Show Limited Utility in Guiding Early TAVR Timing for Asymptomatic Severe AS: EARLY TAVR Trial
Key Takeaways: Elevated baseline NT-proBNP and hs-cTnT levels were associated with higher cardiovascular event rates, but did not predict greater relative benefit... Read more.
Autologous Bone Marrow Cell Therapy Failed to Meet Primary Endpoint in Ischemic Heart Failure: CardiAMP-HF
Key Takeaways: Intramyocardial autologous bone marrow cell therapy was safe in patients with ischemic HFrEF but did not meet its primary efficacy outcome using the... Read more.
SHR-1918 Safe, Significantly Lowered LDL-C and Triglycerides in Poorly Controlled Hyperlipidemia
Key Takeaways: SHR-1918, an ANGPTL3 inhibitor, significantly reduced LDL cholesterol by approximately 22–30% and triglycerides by 52–63% in patients with ASCVD... Read more.
AI-Based ECG Model Enhances Detection of Heart Attack and Need for Coronary Revascularization
Key Takeaways: A deep learning ECG model significantly outperforms clinician interpretation in rapidly identifying patients who require coronary revascularization... Read more.