Full-Body Embolic Protection With Emboliner Non-inferior to Sentinel With Superior Debris Capture During TAVR: PROTECT H2H Trial
Key Points Embolic complications remain a key concern during transcatheter aortic valve replacement (TAVR), with debris dislodgement contributing to stroke and potential... Read more.
Deferral of PCI Non-inferior to Routine Revascularization Before TAVI in Patients with CAD: PRO-TAVI Trial
Key Points Coronary artery disease (CAD) is present in approximately half of patients undergoing transcatheter aortic valve implantation (TAVI), yet the optimal... Read more.
Angiography-Derived FFR Noninferior to Pressure-Wire Guidance for PCI Decision-Making: ALL-RISE Trial
Key Points Physiologic lesion assessment using fractional flow reserve (FFR) is a cornerstone of contemporary coronary revascularization, with guideline recommendations... Read more.
Elective Left Ventricular Unloading Does Not Improve Outcomes in High-Risk PCI: CHIP-BCIS3 Trial
Key Points Complex PCI in patients with severe left ventricular dysfunction remains at high risk, and mechanical circulatory support has been increasingly adopted... Read more.
Ultrasound-Facilitated Catheter-Directed Fibrinolysis Reduces Early Clinical Deterioration in Intermediate-Risk Pulmonary Embolism: HI-PEITHO Trial
Key Points Acute pulmonary embolism (PE) remains a leading cause of cardiovascular morbidity and mortality, particularly in patients with intermediate-risk disease... Read more.
CorCMR: Stress Cardiac MRI Uncovers Hidden Angina and Improves Quality of Life in Patients Without Obstructive Coronary Disease
Key Points: Stress cardiac MRI (CMR) enhanced diagnostic accuracy for patients with angina but no obstructive coronary artery disease, identifying microvascular... Read more.
CELEBRATE: Early Pre-hospital Subcutaneous Zalunfiban Improves Coronary Patency and Outcomes in STEMI Without Increasing Severe Bleeding
Key Points: Early pre-hospital administration of subcutaneous zalunfiban improved coronary patency and reduced composite adverse outcomes at 30 days in patients... Read more.
FAVOR IV-QVAS: Angio-FFR–Guided CABG During Valve Surgery Improves Outcomes
Key Points: The FAVOR IV-QVAS trial tested the hypothesis physiology-guided coronary artery bypass grafting (CABG) using angiography-derived fractional flow reserve... Read more.
Early Surgery Provides Durable Survival Advantage in Asymptomatic Severe Aortic Stenosis: Final 10-Year Outcomes from the RECOVERY Trial
Key Points: Over a decade of follow-up, early surgical aortic valve replacement (AVR) continued to confer a substantial survival advantage over conservative management... Read more.
CLOSURE-AF: Left Atrial Appendage Closure Fails to Achieve Noninferiority to Medical Therapy in AF Patients With High Bleeding Risk
Key Points: The CLOSURE AF study compared catheter-based left atrial appendage closure with physician-directed standard medical care (including timely anticoagulant... Read more.