First-in-human Trial of CRISPR Gene-editing ANGPTL3 Safely Lowered Cholesterol and Triglycerides
Key Points: CTX310 is a first-in-class in vivo CRISPR-Cas9 therapy designed to…
Tirzepatide Lowers MACE vs Dulaglutide in SURPASS-CVOT Patients With Heart Failure
Key Points In SURPASS-CVOT, tirzepatide was previously shown to be non-inferior to…
PCSK9-inhibitors Do Not Reduce Early Cardiac Allograft Vasculopathy: The CAVIAR Trial
Key Points The CAVIAR trial enrolled recent heart transplant recipients to receive…
NOAC Monotherapy Non-Inferior to Combination Therapy for Net Adverse Clinical events in AF Patients Post–DES: ADAPT AF-DES Trial
Key Points The ADAPT AF-DES randomized trial compared NOAC monotherapy (apixaban or…
Prasugrel Might be a Better Choice than Ticagrelor For DAPT after PCI for Patients with Diabetes and MVD: The TUXEDO-2 Trial
Key Points TUXEDO-2 directly compared ticagrelor vs prasugrel based DAPT in 1,800…
CorCMR: Stress Cardiac MRI Uncovers Hidden Angina and Improves Quality of Life in Patients Without Obstructive Coronary Disease
Key Points: Stress cardiac MRI (CMR) enhanced diagnostic accuracy for patients with…
CELEBRATE: Early Pre-hospital Subcutaneous Zalunfiban Improves Coronary Patency and Outcomes in STEMI Without Increasing Severe Bleeding
Key Points: Early pre-hospital administration of subcutaneous zalunfiban improved coronary patency and…
FAVOR IV-QVAS: Angio-FFR–Guided CABG During Valve Surgery Improves Outcomes
Key Points: The FAVOR IV-QVAS trial tested the hypothesis physiology-guided coronary artery…
VESALIUS-CV: PCSK9-Inhibitor Evolocumab Reduces MACE for Primary Prevention
Key Points: PCSK9-inhibitors – including evolocumab – are highly effective LDL-C–lowering medications…
Remote Acute Assessment Of Patients With High Cardiovascular Risk Post-Acute Coronary Syndrome (TELE-ACS)
Key Points: TELE-ACS evaluates the use of telemedicine strategies to reduce hospital…
OPTION –Indobufen is Noninferior to Aspirin After Coronary Drug-Eluting Stent Implantation
Key Points: Indobufen, a platelet aggregation inhibitor, has been shown to be…
PRECISE–A precision diagnostic strategy in patients with suspected CAD improves outcomes
Key Points: There is substantial heterogeneity in the use of different non-invasive…
RAPCO: Radial artery grafting is superior to both RITA and SVG in patients undergoing CABG
Key Points: Recent guidelines have supported the use of arterial grafts over…
CTS-AMI: Tongxinluo (TXL) improves CV outcomes in acute STEMI
Key Points: Tongxinluo (TXL) is a traditional Chinese medicine with endothelial-protective effects…
PROMINENT: Pemafibrate reduces triglyceride levels but not cardiovascular events in patients with dyslipidemia and T2DM
Key Points High triglyceride levels are associated with increased cardiovascular risk, but…
EPIC-STEMI: Early Routine PCSK-9 Use Added to High Intensity Statin Reduces LDL after Primary PCI for STEMI
Key Points: Early high-intensity statin therapy is standard of practice in acute…
Extended outcomes of BEST: No difference in MACE between PCI and CABG in MVD at 12 years, but higher repeat revascularization and spontaneous MI in PCI arm
Key Points: Previous studies have demonstrated the superiority of CABG over PCI…
Study Shows Patient Self Reports Overestimated And Pharmacy Fills Underestimated Medication Persistence
In an original investigation done by Dr. Alexander C. Fanaroff et al and…
Study Shows Inconsistency in Identifying the Infarct Related Artery by Angiography When Compared to Cardiac Magnetic Resonance Imaging
A new study led by Dr. John Heitner, published in Circulation: Cardiovascular…
Depression Is Associated with More Severe Angina and Dyspnea in Patients with Chronic Total Occlusion
A study led by Dr. Robert Yeh that was published in JACC:…