UK Biobank Analysis: Self-reported LCHF Diet May be Linked to Cardiac Events
Key Points: In spite of the increase popularity of low-carbohydrate high-fat diet due to purported benefit in a variety of conditions, there is limited data on the... Read more.
hsCRP is a Stronger Predictor of CV Events and Death than LDL-C in High-Risk Patients on Statins
Key Points: Both inflammatory risk and hyperlipidemia and crucial risk factors for MACE in patients at high risk of CVD. In a large collaborative study of patients... Read more.
FREEDOM COVID: Therapeutic dose anticoagulation does not reduce MACE in non-critically ill COVID-19 patients
Key Points: There have been conflicting data on the role and recommended dosage of anticoagulation in non-critically-ill patients with COVID-19. In the open-label... Read more.
STELLAR: Sotatercept improves 6MWD in PAH patients and WHO FC II-III
Key Points: Sotatercept is a novel activin signaling inhibitor which was designed to target pulmonary vascular remodeling in PAH. In the STELLAR study, sotatercept... Read more.
Dapagliflozin Reduces PCWP at Rest and Exercise, Plasma Volume, and Weight in HFpEF patients
Key Points: SGLT2i therapy reduces HF hospitalizations and CV mortality in HFpEF, but the mechanism is not yet clear. In this single-center, double-blinded RCT,... Read more.
A Novel, Oral, PSCK-9 Inhibitor Showed Significant and Dose-dependent Reduction of LDL compared to Placebo
Key Points -Lowering LDL-C is known to reduce the risk of ASCVD -In patients at very high risk for ASCVD or in those with intolerance to statins, PCSK-9 inhibitors... Read more.
LIVE HCM Trial: Vigorous Exercise in Patients with HCM Not Associated with Increased Risk of Adverse Cardiac Events
Key Points -HCM is the most common cause of sudden cardiac death in athletes -In patient diagnosed with HCM, long-established guidelines have advocated against vigorous... Read more.
The future is now: A wrist-worn Sensor Coupled with AI Accurately Predicts Troponin Elevation in ACS Patients
Key Points – Prompt identification of patients suffering from ACS requires measurements of the blood level of the cardiac troponin biomarker, which is traditionally... Read more.
Low Cardiac Risk for Elite Level Athletes With Genetic Heart Disease
Key Points -Patients with diagnosed sudden cardiac death (SCD)-predisposing genetic heart diseases (GHDs) have traditionally been restricted from participating in... Read more.
Macitentan/Tadalafil Fixed Dose Combination reduces PVR compared with monotherapy
Key Points: Macitentan and Tadalfil are frequently used in combination for PAH, which opens up the possibility of a fixed-dose combination pill. In the DUE study,... Read more.