TEAMMATE Trial: Everolimus with Low-Dose Tacrolimus to Prevent Rejection in Children after Cardiac Transplantation
Key Points This was the first randomized trial to evaluate the safety…
Percutaneous Coronary Intervention Improved Symptoms in Stable Angina: ORBITA-2 trial
Key points: PCI is often performed for chronic stable angina, but current…
Lowering blood pressure significantly reduced dementia risk in people with hypertension in rural China
Key Points: Intensive blood pressure (BP) lowering intervention was tested on hypertensive…
MINT Trial – In Patients with MI and Anemia, Liberal Blood Transfusion not Significantly Different to Restrictive Strategy in Reducing Death or MI
Key Points Anemia is common among individuals with acute myocardial infarction, however,…
DAPA-MI: Dapagliflozin improves clinical and cardiometabolic outcomes in post-AMI patients with impaired LV function versus placebo
Key Points This trial of patients with acute myocardial infarction (AMI) and…
SELECT TRIAL: Semaglutide reduces cardiovascular events among overweight or obese patients with cardiovascular disease in the absence of diabetes
Key Points: Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, has previously been shown…
ARAMIS: Anakinra is safe but does not reduce complications of acute myocarditis
Key Points: While myocarditis is an inflammatory condition, there have not yet…
SGLT2 inhibitors not linked with improved survival in hospitalized COVID-19 patients
Key Points: In hospitalized COVID-19 patients, treatments targeting the virus’s pathobiology (e.g.…
Inorganic nitrate improves safety of coronary angiography in patients at kidney injury risk
Key Points: Contrast-induced nephropathy (CIN) is a clinical condition that refers a…
Atrial Fibrillation ablation improves outcomes in patients with end-stage HF
Key Points Evidence suggests that catheter ablation for atrial fibrillation (AF) is…
DICTATE-AHF Trial: Early Dapagliflozin in AHF does not meet primary endpoint of diuretic efficiency
Key Points: The DICTATE-AHF trial explored early initiation of the SGLT2 inhibitor…
DANPACE II: Minimizing atrial pacing in sinus node dysfunction leads to increased syncope with no difference in development of AF
Key Points This trial randomizing patients with an indication for initial dual…
RIGHT Trial: Anticoagulation shows no benefit after primary PCI in STEMI
Key Points: The RIGHT trial assessed the benefit of post-procedural anticoagulation (PPA)…
OPT-BIRISK: Extended P2Y12 Monotherapy is Superior to Extended DAPT for High Risk ACS Patients
Key Points This trial randomizing patients at high bleeding and/or ischemic risk…
OCTIVUS: OCT- Guided PCI is non-inferior to IVUS-Guided PCI for Clinical Outcomes
Key Points This pragmatic trial randomizing patients to optical coherence tomography (OCT)-guided…
Metanalysis: OCT or IVUS is associated with improved outcomes compared to angiography alone
Key Points This metanalysis integrating data from ILUMIEN IV and OCTOBER Trials…
Addressing the Triple Threat: Proactive Screening Resulted in Improved Early Detection of Coronary Artery Disease, Atrial Fibrillation, and Heart Failure in the RED-CVD Trial
Key Points: Tertiary screening for chronic cardiovascular disease as a means to…
OCTOBER Trial: OCT Reduces MACE in complex bifurcation lesions
Key Points This trial randomizing patients with stable angina, unstable angina (UA),…
ILUMIEN IV: OCT-guided complex PCI led to increased minimal stent area, improved safety, and lower in-stent thrombosis rates but no difference in target vessel failure at 2 years
Key Points This trial randomizing patients with diabetes and/or complex lesions to…
MULTISTARS AMI Trial: Immediate Complete Multivessel PCI non-inferior to staged approach in patients with STEMI and MVD
Key Points: It is well known that patients with STEMI often have…