AT-001, a potent aldose reductase inhibitor, did not improve exercise capacity in diabetic cardiomyopathy with impaired exercise capacity
Key Points: The ARISE-HF trial evaluates the use of AT-001, a potent aldose reductase inhibitor, to reduce the risk of diabetic cardiomyopathy among patients with... Read more.
TAVR non-inferior to SAVR in Low to Intermediate Risk Patients With Severe Aortic Stenosis: DEDICATE-DZHK6 Trial
Key Points In the DEDICATE-DZHK6 trial, patients with a history of severe aortic stenosis who were ≥ 65 years old and low to intermediate risk for surgery were... Read more.
ORBITA COSMIC: Coronary sinus reducer did not improve transmural myocardial perfusion but angina symptoms
Key Points – Coronary sinus reduction (CSR) is a potential therapeutic device for patients with refractory angina – In this first-of-its-kind randomized,... Read more.
TARGET BP I: Alcohol-mediated renal artery denervation reduced SBP in treatment-resistant hypertension at 3 months compared to sham control
Key Points: Achieving hypertension control has remained an elusive goal in the US and globally, and procedural treatments like renal denervation have gained traction... Read more.
Hózhó: Phone-based GDMT Initiation and Uptitration Feasible and Effective among HFrEF patients in Navajo Nation
Key Points: GDMT utilization is suboptimal among American Indian patients with HFrEF in Navajo Nation. In this pragmatic, stepped-wedge, randomized clinical trial,... Read more.
HUDDLE: Cross-sectional study finds large gap between hypertension prevalence and awareness among former NFL athletes
Key Points: Little is known about the prevalence of cardiovascular risk factors or disease in former professional athletes. Gaps may exist between the awareness... Read more.
Health 360x: Medical assistants more likely to complete training and remain in clinical research in community practices
Key Points: Research coordinators embedded in community-based practices can help ensure that underrepresented and underserved patients have equitable point-of-care... Read more.
HeLP: Behavioral interventions improve cardiac rehabilitation attendance among recently hospitalized patients with lower SES
Key Points: Low-SES patients are less likely to attend CR following hospitalization for a major cardiovascular event and are more likely to be readmitted compared... Read more.
MINT subgroup analysis: Among patients with acute MI and anemia, a restrictive transfusion strategy was associated with higher rates of death and MI at 30 days
Key Points: The MINT trial found that among patients with acute MI and anemia, those randomized to a liberal transfusion strategy had lower rates death or MI at... Read more.
Routine Assessment of Patient-Reported Health Status in Academic Clinics Did Not Improve Patient-Reported Health-Status: The PRO-HF Trial
Key Points: The latest AHA/ACC Heart Failure (HF) guidelines recommend routine assessment of patient-reported health status, but no randomized trials have analyzed... Read more.