RIGHT Trial: Anticoagulation shows no benefit after primary PCI in STEMI
Key Points: The RIGHT trial assessed the benefit of post-procedural anticoagulation (PPA)…
OPT-BIRISK: Extended P2Y12 Monotherapy is Superior to Extended DAPT for High Risk ACS Patients
Key Points This trial randomizing patients at high bleeding and/or ischemic risk…
OCTIVUS: OCT- Guided PCI is non-inferior to IVUS-Guided PCI for Clinical Outcomes
Key Points This pragmatic trial randomizing patients to optical coherence tomography (OCT)-guided…
Metanalysis: OCT or IVUS is associated with improved outcomes compared to angiography alone
Key Points This metanalysis integrating data from ILUMIEN IV and OCTOBER Trials…
Addressing the Triple Threat: Proactive Screening Resulted in Improved Early Detection of Coronary Artery Disease, Atrial Fibrillation, and Heart Failure in the RED-CVD Trial
Key Points: Tertiary screening for chronic cardiovascular disease as a means to…
OCTOBER Trial: OCT Reduces MACE in complex bifurcation lesions
Key Points This trial randomizing patients with stable angina, unstable angina (UA),…
ONCO-DVT– 1 Year of Anticoagulation With Edoxaban Is Superior To 3-Months In Cancer Patients With Distal DVT
Key Points: The optimal duration of therapy for distal deep vein thrombosis…
ILUMIEN IV: OCT-guided complex PCI led to increased minimal stent area, improved safety, and lower in-stent thrombosis rates but no difference in target vessel failure at 2 years
Key Points This trial randomizing patients with diabetes and/or complex lesions to…
MULTISTARS AMI Trial: Immediate Complete Multivessel PCI non-inferior to staged approach in patients with STEMI and MVD
Key Points: It is well known that patients with STEMI often have…
FRAIL-AF: Switching to NOACs in Frail Elderly with AF Linked to Increased Bleeding
Key Points: The FRAIL-AF trial is an open-label, randomized controlled trial that…
ARREST: Transfer to a cardiac arrest center instead of the nearest ED does not improve mortality in OHCA patients
Key Points: Sudden cardiac death causes a fifth of all deaths in…
ATTRibute-CM: Acoramidis Linked to Improved clinical outcomes in transthyretin amyloid cardiomyopathy
Key Points: Transthyretin amyloid cardiomyopathy develops because of mis-folded proteins infiltrating the…
The ADVENT of Pulsed Field Ablation for Atrial Fibrillation: just as effective and safe as traditional thermal ablation, but faster
Key Points: ADVENT was the first randomized controlled trial comparing pulsed field…
STOPDAPT-3: Prasugrel monotherapy after PCI with DES not superior to DAPT for major bleeding but non-inferior for CV events
Key Points: This trial randomized 6,000 patients with high bleeding risk or…
FIRE: Complete revascularization better than culprit-only strategy for elderly with MI and MVD
Key Points The FIRE trial aimed to address the lack of evidence…
Meta-analysis demonstrates that IV Iron is associated with reduced HF hospitalizations in HF patients with iron deficiency
Key Points: Iron-deficiency is common in heart failure (HF) and associated with…
ECLS-SHOCK: ECMO does not reduce mortality in acute MI-related cardiogenic shock compared to control
Key Points: The use of ECLS has increased substantially over the past…
QUEST: Chinese Herbal Medicine (Qiliqiangxin) reduces heart failure hospitalizations and cardiovascular mortality in HFrEF
Key Points: Qiliqiangxin is a traditional Chinese herbal medicine extract which has…
HEART-FID Trial: Ferric Carboxymaltose resulted in modest improvement in hierarchical outcomes but did not reach statistical significance
Key Points: Prior data suggest that heart failure with reduced ejection fraction…
Wait no more – HFrEF patients with high RV pacing burden from pacemakers or defibrillators should be promptly upgraded to CRT devices: insights from the BUDAPEST-CRT Upgrade Study
Key Points: A high burden of right ventricular pacing among patients with…