STEP-HFpEF DM TRIAL: Semaglutide improves HF-related symptoms and results in greater weight loss among patients with obesity-related HFpEF and type 2 DM
Key Points: Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, has previously been shown…
Remote Acute Assessment Of Patients With High Cardiovascular Risk Post-Acute Coronary Syndrome (TELE-ACS)
Key Points: TELE-ACS evaluates the use of telemedicine strategies to reduce hospital…
An “Inclisiran First” Strategy Shows Greater LDL-C Lowering Compared With Usual Care In Patients With ASCVD: The VICTORION-INITIATE Randomized Trial
Key Points: Most patients with atherosclerotic cardiovascular disease (ASCVD) do not achieve…
EMPACT-MI: Empagliflozin did not meet primary endpoint but significantly reduced HF hospitalizations
Key Points: Incident heart failure remains common among patients who experience acute…
Self-monitoring and physician-optimized antihypertensive titration post-partum decreases BP during the first 9 months
Key Points: Up to 1 in 10 women experience a hypertensive disorder…
Novel RNA interference therapeutic Zilebesiran results in dose-dependent sustained BP reduction
Key Points: Uncontrolled hypertension is a major public health concern, and this…
VERVE-101, a novel DNA-base editing medication, results in dose-dependent reductions in blood PCSK9 and LDL-C
Key Points: Despite the advent of PCSK9 inhibitors, the majority of patients…
A multi-level hypertension program improved hypertension control in Nigeria
Key Points: The global burden of hypertension is high and increasing, with…
IMPACTS: A multifaceted implementation significantly improved BP control among low-income patients
Key Points This cluster-randomized trial found that a multifaceted implementation strategy to…
SPEECH: Novel speech analysis technology may be useful for early recognition of worsening heart failure events
Key Points Novel speech processing technology has the potential to detect heart…
SUPER-LIPID: Non-visit based automated orders sent to central pharmacy increased appropriate statin prescriptions
Key Points In two simultaneous pragmatic trials, an asynchronous, non-visit based, automated…
Recaticimab Effective as Add-On Therapy in Non-Familial Hypercholesterolaemia and Mixed Hyperlipidemia: REMAIN-2 Trial
Key Points Recaticimab effectiveness demonstrated dosage-dependent response indicating versatility in treatment options.…
Dual Cardioversion More Effective than Single in Obese Patients with AF
Key Points: The prevalence of obesity, and AF is increasing substantially and…
AI -ECG Results in Faster and More Accurate Identification of STEMI
Key Points: The use of an artificial intelligence electrocardiogram (AI-ECG) support tool…
Abelacimab, a novel Factor XI/XIa Inhibitor, reduced bleeding vs Rivaroxaban in AF
Key Points: Previous studies have investigated the use of direct oral anticoagulants…
Coronary Inflammation on CCTA as Predictor of Cardiac Events: the ORFAN Study
Key Points: Out of all patients who undergo a CCTA, the highest…
ESPIRIT: Intensive blood pressure control lowers MACE vs Standard Treatment
Key Points This randomized trial of 11255 patients in China with established…
REPRIEVE Substudy: Pitavastatin reduces non-calcified coronary plaque in people with HIV
Key Points The REPRIEVE trial recently demonstrated that pitavastatin reduced major adverse…
NOAH-AFNET 6: AHRE>24 hours associated with low stroke risk but more likely to develop AF later
Key Points This pre-specific subanalysis of NOAH-AFNET 6 found that those with…
ARTESIA: Apixaban reduces the risk of stroke in subclinical AF, with an increase in major non-fatal bleeding
Key Points This randomized trial of 4012 patients (median age ~77, mean…