STOPDAPT-3: Prasugrel monotherapy after PCI with DES not superior to DAPT for major bleeding but non-inferior for CV events
Key Points: This trial randomized 6,000 patients with high bleeding risk or acute coronary syndrome undergoing planned PCI to a strategy of 3.75mg of prasugrel or... Read more.
Meta-analysis demonstrates that IV Iron is associated with reduced HF hospitalizations in HF patients with iron deficiency
Key Points: Iron-deficiency is common in heart failure (HF) and associated with increased mortality and hospitalization. Previous trials of intravenous (IV) iron... Read more.
ECLS-SHOCK: ECMO does not reduce mortality in acute MI-related cardiogenic shock compared to control
Key Points: The use of ECLS has increased substantially over the past decade despite stagnant, high mortality in cardiogenic shock. This multicenter randomized trial... Read more.
QUEST: Chinese Herbal Medicine (Qiliqiangxin) reduces heart failure hospitalizations and cardiovascular mortality in HFrEF
Key Points: Qiliqiangxin is a traditional Chinese herbal medicine extract which has been approved since 2004 for the treatment of HF in China. This multicenter,... Read more.
HEART-FID Trial: Ferric Carboxymaltose resulted in modest improvement in hierarchical outcomes but did not reach statistical significance
Key Points: Prior data suggest that heart failure with reduced ejection fraction (HFrEF) patients with iron deficiency receiving IV iron supplementation had improvement... Read more.
Wait no more – HFrEF patients with high RV pacing burden from pacemakers or defibrillators should be promptly upgraded to CRT devices: insights from the BUDAPEST-CRT Upgrade Study
Key Points: A high burden of right ventricular pacing among patients with heart failure patients with reduced ejection fraction is known to cause left ventricular... Read more.
STEP-HFpEF: Semaglutide reduces heart failure symptoms and body weight in HFpEF patients at one year
Key Points: More than 80% of patients with HFpEF are overweight or obese, but there has not yet been a study examining the use of weight-loss agents in body weight... Read more.
COP-AF: Colchicine did not reduce AF or myocardial injury after non-cardiac surgery, but post-hoc analysis suggest benefit in composite outcomes
Key Points This trial randomizing patients aged 55 or older to colchicine or placebo following non-cardiac thoracic surgery found no difference in the co-primary... Read more.
NOAH-AFNET 6: No benefit of oral anticoagulation among patients with atrial high-rate episodes in the absence of confirmed AF
Key Points This trial randomized elderly patients without a known diagnosis of atrial fibrillation with device-detected atrial high-rate episodes (AHREs) and a median... Read more.
HOST-IDEA: 3-Month DAPT Noninferior to 12-Month DAPT in Patients Undergoing PCI using third-generation stents
Key Points: Among patients undergoing PCI using third-generation DES with ultrathin struts and advanced polymer technology, 3- to 6-month DAPT was noninferior to... Read more.