Using Causal A.I. to Translate Polygenic Risk for Coronary Artery Disease into Clinically Actionable Information: How much does LDL or SBP need to be lowered to overcome inherited polygenic risk?
Key Points: Polygenic scores (PGS) give insights into a patient’s inherited risk…
Minimally invasive thoracoscopically-guided right mini thoracotomy for mitral valve repair is a safe and effective alternative to conventional sternotomy
Key points : Mitral valve surgery via sternotomy is associated with significant…
TAVR at 3 years showed durable benefits vs surgery: the Evolut Low Risk Trial
Key Points Both transcatheter aortic valve replacement (TAVR) and surgical aortic valve…
TRILUMINATE: Tri-Clip reduces tricuspid regurgitation and improves quality of life at one year
Key Points: There have been limited data examining the safety and efficacy…
FLAME: FlowTriever use for PE associated with decreased in-hospital adverse outcomes
Key Points: Mortality in high-risk PE remains unacceptably high (25%) despite advances…
Atorvastatin Reduced Left Ventricular Dysfunction From Anthracyclines: The STOP-CA Trial
Key Points -Anthracycline therapy is associated with the development of heart…
BrigHTN: Baxdrostat, an aldosterone synthase inhibitor, showed dose-related reductions in blood pressure and safely and effectively lowers blood pressure in patients with resistant hypertension
Key Points In a Phase 2 randomized trial, baxdrostat, a highly potent…
FRESH –First-in-Class Aminopeptidase-A Inhibitor Firibastat Fails in Resistant Hypertension
Key Points Hypertension remains a major public health threat contributing significantly to…
PRECISION –Dual Endothelin Receptor Antagonist Aprocitentan Superior to Placebo in Resistant Hypertension
Key Points Despite the many drug classes available to treat hypertension, the…
RAPID – Self-Administered Etripamil Improves PSVT Conversion to Sinus Rhythm
Key Points -The RAPID study achieved its primary efficacy endpoint of terminating…
NOVA – No significant difference in rate of post-op AF with botulinum toxin vs placebo
Key Points: -In a Phase II, dose-ranging trial of epicardial fat pad…
OPTION –Indobufen is Noninferior to Aspirin After Coronary Drug-Eluting Stent Implantation
Key Points: Indobufen, a platelet aggregation inhibitor, has been shown to be…
PRECISE–A precision diagnostic strategy in patients with suspected CAD improves outcomes
Key Points: There is substantial heterogeneity in the use of different non-invasive…
PRO-HF Sub-Study: Routine KCCQ-12 assessments in HF improves accuracy of provider assessment of patient health status.
Key Points Clinicians estimate heart failure (HF) health status using New York…
RAPCO: Radial artery grafting is superior to both RITA and SVG in patients undergoing CABG
Key Points: Recent guidelines have supported the use of arterial grafts over…
ECMO-CS: Early ECMO Does not Improve Outcomes in Severe Cardiogenic Shock
Key Points: ECMO has been used as a salvage strategy in severe…
CTS-AMI: Tongxinluo (TXL) improves CV outcomes in acute STEMI
Key Points: Tongxinluo (TXL) is a traditional Chinese medicine with endothelial-protective effects…
IRONMAN: Intravenous Ferric Derisomaltose did not not meet primary endpoint in HFrEF
Key Points: Iron deficiency is common and a poor prognostic feature in…
COACH – A Patient-Risk Based Health System Intervention for Acute Heart Failure Care: The Comparison of Outcomes and Access to Care for Heart Failure (COACH) Trial
Key Points: HF patients frequently present to the ED for acute exacerbations,…
First-in-Human in vivo Crispr/Cas9 Editing of the TTR Gene by NTLA-2001 in patients with Transthyretin Amyloid Cardiomyopathy
Key Points: Transthyretin Amyloidosis (ATTR) is a highly morbid and often fatal…