Transcatheter Edge-To-Edge Repair Is Non-Inferior To Surgery In Patients With Secondary Mitral Regurgitation: MATTERHORN Trial
Key Points: The MATTERHORN trial found that the transcatheter edge-to-edge repair (TEER) procedure was non-inferior to surgical mitral valve repair in reducing functional... Read more.
T-TEER Significantly Reduced the Severity of Secondary Tricuspid Regurgitation and Improved Quality of Life. TRI-FR Trial
Key Points: The TRI.FR trial found that tricuspid transcatheter edge-to-edge repair (T-TEER) together with optimal medical therapy significantly improved the clinical... Read more.
ABYSS – Beta Blocker Interruption in Post-Myocardial Infarction Patients
Key Points: In the ABYSS trial, 3700 patients who had a left ventricular ejection fraction ≥ 40% and were > 6 months post myocardial infarction were randomized... Read more.
Vitrusiran Reduces Risk of Death and CV Events in Patients with ATTR-CM
Key Points: ATTR amyloid cardiomyopathy, resulting from accumulation of TTR amyloid protein in the heart, leads to progressive heart failure, complicated by arrhythmias,... Read more.
Consistent Renal Benefits of Semaglutide in CKD and T2DM Patients With or Without SGLT2 Inhibitors Use. FLOW Trial
The FLOW trial showed that among patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), once-weekly subcutaneous semaglutide was superior to placebo... Read more.
Tirzepatide Reduced Apnea-hypopnea Index and Weight in Obese Patients with Moderate Sleep Apnea: SURMOUNT-OSA Trials
Obstructive sleep apnea is associated with cardiovascular complications and is seen more commonly in individuals with excess adiposity. The SURMOUNT OSA phase 3... Read more.
LENS Trial: Fenofibrate Significantly Reduced Progression of Diabetic Retinopathy vs Placebo.
– Findings from cardiovascular trials suggested that fenofibrate therapy may reduce the progression of diabetic retinopathy. – The LENS (Lowering Events... Read more.
A technology assisted Web App allowed >90% of consumers to correctly self-select for statin use and achieve clinically important LDL-C reduction
Key Points: Nonprescription statin access may help statin-eligible patients receive appropriate treatment. This prospective, actual-use study employed a Web App... Read more.
PROACT: Enalapril Does Not Mitigate Anthracycline Toxicity in Breast Cancer and NHL
Key Points: Anthracycline toxicity is an important cause of cardiomyopathy; it is unclear whether prophylactic treatment with ACE inhibitors could mitigate this... Read more.
Topical TXA Does Not Reduce Peri-Operative Seizures but Increases Risk of Transfusion in Cardiac Surgery Compared to Intravenous TXA
Key Points: IV TXA is used to prevent peri-operative bleeding in cardiac surgery, but it carries a risk of seizure. It is hypothesized that topical TXA may reduce... Read more.