EPIC-STEMI: Early Routine PCSK-9 Use Added to High Intensity Statin Reduces LDL after Primary PCI for STEMI
Key Points: Early high-intensity statin therapy is standard of practice in acute…
Extended outcomes of BEST: No difference in MACE between PCI and CABG in MVD at 12 years, but higher repeat revascularization and spontaneous MI in PCI arm
Key Points: Previous studies have demonstrated the superiority of CABG over PCI…
FLASH: The FlowTriever system has an excellent safety profile in the treatment of pulmonary embolism
Key Points: Mortality for acute PE remains high. While percutaneous mechanical thrombectomy…
UNIVERSAL: Routine ultrasound guidance of femoral vascular access did not reduce bleeding or vascular complications but did facilitate access
Key Points: Femoral access is used for 30% of all coronary procedures,…
PADN-CFDA: Pulmonary artery denervation in addition to PDE-5i therapy improves exercise capacity in patients with pulmonary arterial hypertension
Key Points: Pulmonary artery denervation (PADN) has never been studied with a…
RADIANCE II: Endovascular ultrasound denervation met primary/secondary efficacy BP lowering endpoints at 2 months
Key Points: Endovascular ultrasound denervation (uRDN) is a potentially useful technique in…
Amulet IDE: Continued safety and effectiveness of the Amulet LAA occluder device at three years in patients with nonvalvular atrial fibrillation
Key Points: In 2021, the Amulet IDE study demonstrated that the novel…
CLASP IID: The PASCAL system is a safe and beneficial therapy for severe degenerative mitral regurgitation
Key Points: The MitraClip system has been established as a robust platform…
PROTECTED TAVR: No Overall Stroke Reduction With Embolic Protection Devices in TAVR, But Fewer Disabling Strokes
Key Points: Stroke is a feared complication of TAVR. However, the potential…
Novel IL-6 Antibody Crushes CRP in High-risk ASCVD in Phase2
RESCUE, a phase II, trial presented by Paul M. Ridker, MD, Director of…
Colder Is Not Necessarily Better: CAPITAL CHILL Results
Key Points: Survivors of out of hospital cardiac arrest (OHCA) suffer very…
Role for Omecamtiv Mecarbil in Pts with EF
KEY POINTS: An experimental new therapeutic for heart failure, omecamtiv mecarbil is…
Revascularization Shows Benefit at 4 years in ISCHEMIA
Key Points: ISCHEMIA trial patients in the invasive management arm were assessed…
Acute alcohol consumption elevates risk of AF event
Presented as a Late Breaking Clinical Trial at the American College of…
Hyperinvasive Approach Improves Survival in Refractory Out-of-Hospital Cardiac Arrest
It goes without saying that refractory out of hospital cardiac arrest (OHCA)…
No Advantage to Catheter Ablation for Rhythm Control in Atrial Fibrillation
Atrial fibrillation and heart failure are two common, costly medical conditions that…
Hospital-level Intervention Did Not Improve Outcomes or Quality in HFrEF
Key Points: CONNECT-HF, one of the largest heart failure (HF) implementation science…
Pirfenidone Shown to Decrease Fibrosis in Patients with HFpEF
Key Points: Myocardial fibrosis has previously been associated with death and repeat…
Benefits of Sotagliflozin Across Full Spectrum of EF
KEY POINTS: Trials for those with heart failure with preserved ejection fraction…