VERVE-101, a novel DNA-base editing medication, results in dose-dependent reductions in blood PCSK9 and LDL-C
Key Points: Despite the advent of PCSK9 inhibitors, the majority of patients with familial hypercholesterolemia do not meet their LDL-C targets with standard therapies. ... Read more.
A multi-level hypertension program improved hypertension control in Nigeria
Key Points: The global burden of hypertension is high and increasing, with high rates of underdiagnosis and undertreatment. This study implemented a multi-pronged... Read more.
IMPACTS: A multifaceted implementation significantly improved BP control among low-income patients
Key Points This cluster-randomized trial found that a multifaceted implementation strategy to target an SBP <120 among low-income patients cared for at FQHCs... Read more.
SPEECH: Novel speech analysis technology may be useful for early recognition of worsening heart failure events
Key Points Novel speech processing technology has the potential to detect heart failure exacerbations before they happen, and may be better than the conventional... Read more.
SUPER-LIPID: Non-visit based automated orders sent to central pharmacy increased appropriate statin prescriptions
Key Points In two simultaneous pragmatic trials, an asynchronous, non-visit based, automated order for statins placed to a centralized pharmacy significantly increased... Read more.
Dual Cardioversion More Effective than Single in Obese Patients with AF
Key Points: The prevalence of obesity, and AF is increasing substantially and are inextricably linked. Patients with obesity show less response to single-DCCV due... Read more.
AI -ECG Results in Faster and More Accurate Identification of STEMI
Key Points: The use of an artificial intelligence electrocardiogram (AI-ECG) support tool in the evaluation of patient ECGs was associated with a reduction in the... Read more.
Abelacimab, a novel Factor XI/XIa Inhibitor, reduced bleeding vs Rivaroxaban in AF
Key Points: Previous studies have investigated the use of direct oral anticoagulants (DOACs) instead of warfarin for reduction of stroke risk in AF, but the risk... Read more.
Coronary Inflammation on CCTA as Predictor of Cardiac Events: the ORFAN Study
Key Points: Out of all patients who undergo a CCTA, the highest number of cardiac events occurs in patients without obstructive CAD. In patients with non-obstructive... Read more.
ESPIRIT: Intensive blood pressure control lowers MACE vs Standard Treatment
Key Points This randomized trial of 11255 patients in China with established CVD or at least 2 CVD risk factors but without a significantly reduced ejection fraction... Read more.