Acetazolamide results in improved decongestion, faster: results from ADVOR
Key Points: Residual decongestion after a hospitalization for acute decompensated heart failure…
More Evidence For the Newest Guideline Directed Medical Therapy Pillar – Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (The DELIVER Trial)
Key Points: The use of sodium-glucose cotransporter-2 inhibitor (SGLT2i) in heart failure…
No improvement with allopurinol for patients with ischemic heart disease: ALL-HEART
Key Points Allopurinol had previously shown an improvement in exercise time and…
Routine PCI confers no added benefit in severe left ventricular dysfunction: REVIVED
Key Points REVIVED is the first large scale clinical trial to assess…
Sacubitril/Valsartan has no significant effect on cognition: PERSPECTIVE
Key Points There has been a theoretical concern of potential increased amyloid…
Treatment with sodium thiosulfate showed no effect on infarct size in STEMI: GIPS IV
Key Points: In the GIPS-IV study, patients with STEMI were randomized to…
Residual inflammation plays important role in risk of MACE for patients already on lipid-lowering medication: CANTOS Substudy
Key Points: In the original CANTOS, patients with stable CAD post-MI with…
Alarmingly Low Rates of Extraction for CIED Infection Despite National and International Recommendations: a Nationwide Observational Study among Over 10,000 Medicare Patients
Key Points Prompt and complete removal of CIED systems is strongly recommended…
Less Structural Valve Deterioration at 5 years with TAVR: Insights from CoreValve/SURTAVI Trials
Key Points: As transcatheter aortic valve replacement (TAVR) has experienced expanded indications…
CLASP-TR demonstrates significant improvement in tricuspid regurgitation up to one year after procedure.
Key Points Tricuspid regurgitation is a debilitating valve disorder characterized by shortness…
The PARTITA Trial: VT Ablation After the First Episode of VT Treated with Shock is Superior to Conservative Treatment Among Patients with Ischemic and Non-Ischemic Cardiomyopathy.
Key Points While VT ablation has been associated with improved survival, the…
Patirometer allows for maintenance of target doses of GDMT in patients with hyerkalemia: DIAMOND trial
Key Points Optimal medical therapy for patients with Heart Failure with Reduced…
Uncoupling Hemostasis from Thrombosis: A Promising Comparison of Oral FXIa Inhibitor Asundexian Versus Apixaban in Patients with Atrial Fibrillation – But More Data Are Needed.
Key Points Selective XIa inhibitor Asundexian may innovate the field of oral…
Alirocumab initiation after MI associated with lower plasma atheroma volume: PACMAN-AMI
Key Points PCSK-9 inhibitors have emerged as a viable treatment option patients…
Mavacamten improves LVOT gradients in patients with HCM: EXPLORER-LTE
Key Points: In the EXPLORER-LTE study, patients with severely symptomatic obstructive HCM…
Vupanorsen shown to effectively decrease non-HDL cholesterol in patients already on statins: TRANSLATE-TIMI 70
Key Points: A need for various lipid-lowering agents to combat high cholesterol…
Reduction in Lp(a) possible with siRNA therapy: APOLLO
Key Points: In the Phase I APOLLO study, patients without known ASCVD…
FAME 3 sub-study shows no difference in quality of life between FFR-guided PCI and CABG.
Key Points PCI has yet to be shown to be superior to…
Effects of Diltiazem on Coronary Vasomotor Dysfunction: EDIT-CMD
Key Points: In the EDIT-CMD study, patients with coronary vasomotor dysfunction (encompassing…
More Improvement in Residual Angina and Quality of Life in Complete Revascularization.
Key Points The COMPLETE trial, published in 2019, demonstrated that in patients…