EMPEROR PRESERVED sub-study shows no difference in outcomes when stratified by ejection fraction.
Key Points: In the original EMPEROR-PRESERVED study, patients with chronic heart failure with preserved ejection fraction (EF>40%) with or without diabetes were... Read more.
Icosapent Ethyl Shows Signal but Not Significance for Clinical Improvement in COVID-19 Outpatients – The PREPARE-IT 2 Trial
Key Points: Icosapent ethyl (IPE) had previously shown a signal for improvement in COVID-19 symptoms and decreased inflammatory marker levels in COVID-19 patients... Read more.
Ticagrelor Finds a Quick, Effective Reversal Agent in Bentracimab: REVERSE-IT Early Data
Key Points: To date, P2Y-12 inhibitors do not have a commercially approved reversal agent. The use of ticagrelor, which unlike clopidogrel and prasugrel, reversibly... Read more.
AXIOMATIC-TKR: Milvexian a Success for Prevention of Venous Thromboembolism after Elective Knee Arthroplasty
Key Points: Milvexian is a first-in-class rapidly absorbed oral Factor XIa inhibitor being tested for safety and efficacy for prevention and treatment of venous... Read more.
Aspirin Not Proven to Prevent Dementia and Cognitive Impairment – Results of the ASCEND Trial
Key Points: The ASCEND trial sought to determine whether low-dose aspirin could prevent dementia in >15,000 older individuals in the United Kingdom The randomized... Read more.
Can Your Fitbit Accurately Detect Atrial Fibrillation? Results of The Fitbit Heart Study
Key Points Wearable technologies have optical photoplethysmography (PPG) sensors to measure heart rate coupled with software algorithms that can infer the presence... Read more.
Canaglifozin associated with Improved Quality of Life, Regardless of Ejection Fraction or Diabetes
CHIEF-HF Key Points: In the CHIEF-HF study, patients with HF of any ejection fraction with or without diabetes were treated with either canagliflozin or placebo... Read more.
Avoiding triggers for Atrial Fibrillation has no effect on Quality of Life: results from I-STOP-A-FIB show
Key Points: Interest in this study was generated by patients with atrial fibrillation, who wanted to know if avoiding triggers really did create an impact. The design... Read more.
EHR-Derived Risk Estimates for Clinicians Do Not Change Heart Failure Patient Outcomes – The REVeAL-HF Trial
Key Points: Previously, the impact of risk prediction on clinical decision-making and outcomes in heart failure had not been tested in a randomized control trial... Read more.
Coffee-drinkers rejoice: caffeine consumption not associated with atrial arrhythmias (in young, healthy patients): CRAVE shows
Key Points: Conventional medical wisdom warns against excessive coffee and/or caffeine consumption due to the perceived risk of arrhythmia. Most evidence against... Read more.