Oral NLRP3 Inhibitor, Parunoflast, Reduces Inflammation Alone and in Combination with Semaglutide in Phase 2a Trial
Key Points Inflammation plays a central role in atherosclerosis, with activation of the NLRP3 inflammasome driving production of interleukin-1β and interleukin-18... Read more.
Mavacamten Improves LVOT Obstruction in Adolescents with Symptomatic Obstructive HCM in Phase 3 SCOUT-HCM Trial
Key Points Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease, and pediatric-onset disease is associated with a worse prognosis... Read more.
PCI Improves Angina vs Placebo in Symptomatic Single-Vessel CTO: ORBITA-CTO Trial
Key Points Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is recommended for patients with refractory angina despite medical therapy; however,... Read more.
Invasive Coronary Function Testing Identifies High Prevalence of Vasomotor Disorders and Drives Diagnostic Reclassification
Key Points Invasive coronary function testing: Ischemia with nonobstructive coronary arteries (INOCA) is increasingly recognized as a common and clinically significant... Read more.