AI -ECG Results in Faster and More Accurate Identification of STEMI
Key Points: The use of an artificial intelligence electrocardiogram (AI-ECG) support tool…
Abelacimab, a novel Factor XI/XIa Inhibitor, reduced bleeding vs Rivaroxaban in AF
Key Points: Previous studies have investigated the use of direct oral anticoagulants…
Coronary Inflammation on CCTA as Predictor of Cardiac Events: the ORFAN Study
Key Points: Out of all patients who undergo a CCTA, the highest…
ESPIRIT: Intensive blood pressure control lowers MACE vs Standard Treatment
Key Points This randomized trial of 11255 patients in China with established…
REPRIEVE Substudy: Pitavastatin reduces non-calcified coronary plaque in people with HIV
Key Points The REPRIEVE trial recently demonstrated that pitavastatin reduced major adverse…
NOAH-AFNET 6: AHRE>24 hours associated with low stroke risk but more likely to develop AF later
Key Points This pre-specific subanalysis of NOAH-AFNET 6 found that those with…
ARTESIA: Apixaban reduces the risk of stroke in subclinical AF, with an increase in major non-fatal bleeding
Key Points This randomized trial of 4012 patients (median age ~77, mean…
Novel siRNA targeting therapy lepodisiran results in a dose-dependent and sustained reduction in Lipoprotein(a)
Key Points: There are currently no approved targeted therapies for the reduction…
ARIES-HM3: Aspirin avoidance Is safe and reduces bleeding events in patients with HM3 LVAD on VKA
Key Points: Since the advent of novel HeartMate 3 LVAD technology with…
POCKET-COST-HF: Comprehensive Cost Disclosure improves cost-informed decision making
Key Points: Out-of-pocket costs for GDMT in HFrEF have risen substantially with…
Dietary sodium reduction significantly lowered BP in middle-aged to elderly adults
Key Points: Daily sodium intake remains high (on average ~3,500 mg/day), despite…
TEAMMATE Trial: Everolimus with Low-Dose Tacrolimus to Prevent Rejection in Children after Cardiac Transplantation
Key Points This was the first randomized trial to evaluate the safety…
Percutaneous Coronary Intervention Improved Symptoms in Stable Angina: ORBITA-2 trial
Key points: PCI is often performed for chronic stable angina, but current…
Lowering blood pressure significantly reduced dementia risk in people with hypertension in rural China
Key Points: Intensive blood pressure (BP) lowering intervention was tested on hypertensive…
MINT Trial – In Patients with MI and Anemia, Liberal Blood Transfusion not Significantly Different to Restrictive Strategy in Reducing Death or MI
Key Points Anemia is common among individuals with acute myocardial infarction, however,…
DAPA-MI: Dapagliflozin improves clinical and cardiometabolic outcomes in post-AMI patients with impaired LV function versus placebo
Key Points This trial of patients with acute myocardial infarction (AMI) and…
ARAMIS: Anakinra is safe but does not reduce complications of acute myocarditis
Key Points: While myocarditis is an inflammatory condition, there have not yet…
PUSH-AHF: Natriuresis-guided diuresis approach increases natriuresis and diuresis without improving all-cause mortality or HF hospitalization
Key Points: Diuretic requirement Is a major contributor to hospital length-of-stay for…
SGLT2 inhibitors not linked with improved survival in hospitalized COVID-19 patients
Key Points: In hospitalized COVID-19 patients, treatments targeting the virus’s pathobiology (e.g.…
Inorganic nitrate improves safety of coronary angiography in patients at kidney injury risk
Key Points: Contrast-induced nephropathy (CIN) is a clinical condition that refers a…