In-Hospital Dapagliflozin Does Not Reduce CV Death or Worsening HF in Two Months, but Meta-Analysis Signals Potential Early Benefit
Key Points: Dapagliflozin is a key component of GDMT for heart failure,…
AI-Powered Virtual Assistant Boosts GDMT Optimization. ASSIST-HF SIRIO
Key Points: Optimization of GDMT is critical, particularly in the initial months…
Altshock2: No Benefit to IABP in HF-Cardiogenic Shock
Key Points: Prior trials have demonstrated limited benefit to intra-aortic balloon pump…
No Benefit to Fluid Restriction in Chronic HF: FRESH UP
Key Points: While fluid restriction is a standard recommendation for patients with…
Sodium Zirconium Cyclosilicate Enables MRA Optimization in HFrEF with Hyperkalemia: Insights from the REALIZE-K Trial
Key Points: REALIZE-K trial was a double-blind, placebo-controlled, randomized withdrawal study investigating…
Enhanced Efficiency and Accuracy in Echocardiographic Workflow: Insights from the AI-ECHO RCT
Key Points: AI-ECHO RCT is the first randomized trial to evaluate AI-based…
Obicetrapib Demonstrates Promising Lipid-Lowering Efficacy and Safety in Heterozygous Familial Hypercholesterolemia: BROOKLYN
Key Points: BROOKLYN was a phase III trial that assessed the safety…
Acoramidis: Open-Label Extension Data Confirms Sustained Benefits in Transthyretin Cardiac Amyloidosis
Key Points: Sustained Efficacy: Continued improvements in cardiac biomarkers, functional capacity, and…
Geographic Variations in Racial Disparities for Peripheral Artery Disease Treatment in the U.S.
Key Takeaways: Black patients with peripheral artery disease (PAD) had significantly higher…
Mitral Annular Calcification Severity Predicts Outcomes in Severe Aortic Stenosis Patients Undergoing TAVR
Key Points: The presence of mitral annular calcification (MAC) in prior studies…
Impact of Technology-Enabled Home-Based Cardiac Rehabilitation on Functional Status and Cardiovascular Health Metrics: mTECH-Rehab Trial
Key Points: Cardiac rehabilitation (CR) is a guideline-directed multifaceted intervention that is…
Zerlasiran Was Well Tolerated and Reduced Time-averaged Lp(a) Concentration: The ALPACAR Trial
Key Takeaways: Zerlasiran, a short interfering RNA (siRNA) targeting lipoprotein(a) (Lp(a)), was…
AMULET IDE Trial 5 years Showed Long-term Safety and Efficacy of AMPLATZER Amulet and Watchman Device in LAAO
Key Takeaways: The AMULET IDE trial compared the AMPLATZER Amulet occluder with…
ATTR-Specific Medication and AVR Improve Survival in Patients with Aortic Stenosis and ATTR Cardiac Amyloidosis
Key Takeaways: In this international registry, 266 patients with dual pathology, aortic…
Bempedoic Acid Reduces Major Adverse Limb Events in Patients with PAD : A Pre-specified Analysis from the CLEAR Outcomes Trial
Key Points: Patients with peripheral artery disease (PAD) at an increased risk…
Consistent Efficacy and Safety of Finerenone in Women and Men: A Secondary Analysis of the FINEARTS-HF Trial
KEY POINTS: Historically women have been underrepresented in cardiovascular clinical trials, however,…
Oral Muvalaplin Lowered Lipoprotein(a): The KRAKEN Trial
Key Takeaways: KRAKEN was an international, multicenter, placebo controlled, phase 2 trial…
Rivaroxaban for 18 Months Superior to 6 Months To Prevent Recurrent VTE Events in Cancer Patients with Acute-low PE: ONCO PR
Key Takeaways: The ONCO PE trial demonstrated that an 18-month treatment with…
Promising Cardioprotective Effect of ARNi in High-Risk Cancer Patients Treated with Anthracycline Chemotherapy: SARAH
Key Points: Anthracycline (ANT)-based chemotherapy is a known cancer treatment regimen but…
Semaglutide Improves CV Outcomes in Patients with Prior Coronary Artery Bypass Surgery: Insights from the SELECT Trial
Key Takeaways: In this secondary analysis of the SELECT Trial, semaglutide 2.4…