POLY-HF: Polypill for HFrEF Shows Promise in Reducing Medication Burden Among Underserved Patients
Key Points: Patients with heart failure with reduced ejection fraction (HFrEF) often…
ABLATION Trial – Biatrial Ablation During Mitral Valve Surgery Better than LA Ablation Alone
Key Points: Persistent atrial fibrillation (AF) is common among patients with rheumatic…
OPTIMA-AF Trial – One-month Dual Therapy After PCI Non-inferior to 12 Months, With Lower Bleeding in AF Patients
Key Points: • In patients with atrial fibrillation (AF) undergoing PCI, prolonged…
DARE-AF Trial: Dapagliflozin Did Not Reduce AF Burden After Catheter Ablation
Key Points: SGLT2 inhibitors have shown potential antiarrhythmic benefits in cardiometabolic disease,…
META-AF Trial – Metformin Reduces Arrhythmia Recurrence After AF Ablation in Overweight, Non-diabetic Patients
Key Points: Obesity is a well-established risk factor for atrial fibrillation (AF)…
ABC-AF Trial: Personalized Risk-Based Treatment Did Not Improve Outcomes in Patients with Atrial Fibrillation
Key Points: The ABC-AF trial evaluated whether treatment recommendations based on biomarker-based…
BaxHTN: Baxdrostat Significantly Reduced Blood Pressure in Patients with Uncontrolled or Resistant Hypertension
Key Points: Uncontrolled and resistant hypertension remains a major challenge despite treatment…
HI-PRO Trial: Extended Low-Intensity Apixaban Reduces Recurrent VTE in Patients with Provoked VTE and Enduring Risk Factors
Key Points: Standard anticoagulation for provoked venous thromboembolism (VTE) is often discontinued…
MAPLE-HCM: Aficamten Superior to Metoprolol for Improving Exercise Capacity in Symptomatic Obstructive HCM
Key Points: Beta-blockers are widely used as first-line therapy for obstructive hypertrophic…
LOSE-AF: Weight Loss Alone Does Not Improve AF Symptoms or Burden in Older Adults
Key Points: LOSE-AF is the first randomized trial to rigorously assess the…
PRAGUE-25: Lifestyle Modification Plus Antiarrhythmic Drugs Inferior to Catheter Ablation In Obese Patients
Key Points: Obesity increases the risk of atrial fibrillation (AF) by 19–29%…
ZENITH Trial: Sotatercept Significantly Reduces Major Morbidity and Mortality Events in High-Risk PAH Patients
Key Points: Pulmonary arterial hypertension (PAH) is a progressive disease with poor…
Evolut Low Risk Trial: TAVR Non-inferior to Surgical AR at 5 Years in Low-Risk Patient With Severe AS
Key Points: In the initial Evolut Low Risk Trial, patients with severe…
FAIR-HF2 Trial: IV Iron Improves Quality of Life But Not CV Events in Heart Failure
Key Points: Iron deficiency is common in patients with heart failure with…
API-CAT Trial: Extended Reduced-Dose Apixaban Non-Inferior to Full Dose for VTE in Cancer
Key Points: Venous thromboembolism (VTE) is a leading cause of mortality in…
RIVAWAR Trial: Rivaroxaban Is Comparable to Warfarin for Post-MI Left Ventricular Thrombus
Key Points: Left ventricular thrombus (LVT) is a serious complication following heart…