Consistent Renal Benefits of Semaglutide in CKD and T2DM Patients With or Without SGLT2 Inhibitors Use. FLOW Trial
The FLOW trial showed that among patients with chronic kidney disease (CKD)…
Tirzepatide Reduced Apnea-hypopnea Index and Weight in Obese Patients with Moderate Sleep Apnea: SURMOUNT-OSA Trials
Obstructive sleep apnea is associated with cardiovascular complications and is seen more…
LENS Trial: Fenofibrate Significantly Reduced Progression of Diabetic Retinopathy vs Placebo.
- Findings from cardiovascular trials suggested that fenofibrate therapy may reduce the…
IVUS-Guided DES Reduced MACE at 1 year Compared to Angiography-Guided PCI: IVUS-ACS Trial
Key Points: The IVUS-ACS trial assessed whether the use of intravascular ultrasound…
IVUS -DBC: IVUS-guided drug-coated balloon angioplasty improves primary patency
Key Points: One-year success rates of angioplasty in peripheral artery disease (PAD)…
A technology assisted Web App allowed >90% of consumers to correctly self-select for statin use and achieve clinically important LDL-C reduction
Key Points: Nonprescription statin access may help statin-eligible patients receive appropriate treatment.…
PROACT: Enalapril Does Not Mitigate Anthracycline Toxicity in Breast Cancer and NHL
Key Points: Anthracycline toxicity is an important cause of cardiomyopathy; it is…
IMPROVE-HCM: Cardiac Mitotrope -Ninerafaxstat- Improves Functional Capacity in Symptomatic Non-Obstructive HCM
Key Points: Despite the high symptomatic burden, very few effective treatments exits…
A Restrictive Benzodiazepine Strategy During Cardiac Surgery Does Not Reduce Post-Operative Delirium
Key Points: Benzodiazepine use contributes to delirium before and after cardiac surgery,…
TRAVERSE: Transseptal approach to LV ablation results in fewer cerebral emboli compared to retrograde aortic approach
Key Points: Among patients who undergo endocardial ablation for left ventricular arrythmias,…
FFR-Guided Complete Revascularization in STEMI did not reduce MACE vs Culprit-lesion only PCI: The FULL REVASC Trial
Key Points Researchers compared outcomes in patients with STEMI or very-high-risk non-STEMI…
PREVENT: PCI of non-flow-limiting vulnerable plaques reduced MACE compared to medical therapy alone
Key Points: Vulnerable plaques can lead to acute coronary syndromes, but it…
PERFORM-TAVR: Home based exercise and protein supplementation improves physical performance in frail adults post-TAVR
Key Points: Many frail patients experience poor physical performance after TAVR, even…
EMBO-ABL: Cryoballoon non-inferior to radiofrequency catheter ablation for AF for silent cerebral events
Key Points: Among AF patients undergoing catheter ablation, cryoballoon was non-inferior compared…
RELIEVE HF: Inter-Atrial Shunting Does Not Reduce Symptoms or Improve Prognosis in HF
Key Points: Inter-atrial shunting (IAS) may provide a useful opportunity to dynamically…
SHASTA 2: Novel RNAi Therapeutic Plozasiran Results in Sustained Reduction In Triglycerides in Severe Hypertriglyceridemia
Key Points: Severe hypertriglyceridemia portends high risk of both CVD and acute…
DanGer Shock: Impella Reduces All-Cause Mortality in STEMI Cardiogenic Shock
Key Points: Cardiogenic shock (CS) mortality remains high despite increased utilization of…
AT-001, a potent aldose reductase inhibitor, did not improve exercise capacity in diabetic cardiomyopathy with impaired exercise capacity
Key Points: The ARISE-HF trial evaluates the use of AT-001, a potent…
TAVR non-inferior to SAVR in Low to Intermediate Risk Patients With Severe Aortic Stenosis: DEDICATE-DZHK6 Trial
Key Points In the DEDICATE-DZHK6 trial, patients with a history of severe…
ORBITA COSMIC: Coronary sinus reducer did not improve transmural myocardial perfusion but angina symptoms
Key Points - Coronary sinus reduction (CSR) is a potential therapeutic device…