RESOLVE-1: Oral Ruvonoflast Reduces Inflammatory Biomarkers in Phase 2 Trial
Key Points: Inflammation is mechanistically linked to atherogenesis, plaque progression, and recurrent cardiovascular events, yet anti-inflammatory treatment options... Read more.
HI-PRO: One Year of Low-Dose Apixaban Lowers Two-Year VTE Recurrence in Provoked Thromboembolism
Key Points: Decisions about the duration of anticoagulation after venous thromboembolism (VTE) are guided by whether the event was provoked or unprovoked, while... Read more.
Two-Lead CRT-DX System Without Atrial Pacing Non-Inferior to Conventional Three-Lead CRT-D: Results from the CRT-NEXT Trial
Key Points: Cardiac resynchronization therapy (CRT) has become a cornerstone treatment for those with reduced ejection fraction and left bundle branch block. Standard... Read more.
AI-Based ECG Screening for Structural Heart Disease Demonstrates Moderate Performance in a Community Setting: Results from the PREVUE-VALVE Study
Key Points: With an aging population, the incidence and prevalence of valvular heart disease (VHD) and broader structural heart disease (SHD) are rising. Despite... Read more.
First-in-Human Gene Therapy for PKP2-Arrhythmogenic Cardiomyopathy Safe and Dose-Dependent PKP2 Protein Restoration: HEROIC-PKP2 Trial
Key Points: Arrhythmogenic cardiomyopathy (ACM) is a rare inherited cardiac disorder characterized by progressive fibro-fatty replacement of the myocardium, ventricular... Read more.
Lung Impedance–Guided Therapy Reduces Hospitalizations and Mortality in HFpEF: Results from the IMPEDANCE-HFpEF Trial
Key Points: Patients with heart failure with preserved ejection fraction (HFpEF) are often marred by significant morbidity with recurrent hospitalizations. A critical... Read more.
Transcutaneous Autonomic Neuromodulation Is Safe But Did Not Reduce BP in Uncontrolled Hypertension: SCRATCH-HTN
Key Points: Despite the availability of multiple effective antihypertensive drug classes, blood pressure (BP) control remains a persistent public health challenge,... Read more.
FFR-Guided PCI Associated with Higher Rates of MI Compared to CABG in MVD: Five-Year Results from FAME-3
Key Points: The FAME 3 trial tested whether percutaneous coronary intervention (PCI) could offer comparable long-term outcomes to coronary artery bypass grafting... Read more.
Sudden Cardiac Arrest Survival Worse in Minorities Among Young Athletes: RACER Cohort from 2010–2023
Key Points: This study presents updated national data from the Race Associated Cardiac Event Registry (RACER) on cardiac arrest incidence and outcomes during long-distance... Read more.
AI Accurately Detected Severe AS on TTE but Uptake Low Amongst Clinicians: Insights from a Randomized Crossover Study
Key Points: In a randomized crossover study, authors assessed whether artificial intelligence (AI) can improve accuracy of cardiologists when evaluating echocardiograms... Read more.