TAVR non-inferior to SAVR in Low to Intermediate Risk Patients With Severe Aortic Stenosis: DEDICATE-DZHK6 Trial
Key Points In the DEDICATE-DZHK6 trial, patients with a history of severe aortic stenosis who were ≥ 65 years old and low to intermediate risk for surgery were randomized to…
ORBITA COSMIC: Coronary sinus reducer did not improve transmural myocardial perfusion but angina symptoms
Key Points - Coronary sinus reduction (CSR) is a potential therapeutic device for patients with refractory angina - In this first-of-its-kind randomized, placebo-controlled, double-blind trial, participants underwent CSR implantation or…
TARGET BP I: Alcohol-mediated renal artery denervation reduced SBP in treatment-resistant hypertension at 3 months compared to sham control
Key Points: Achieving hypertension control has remained an elusive goal in the US and globally, and procedural treatments like renal denervation have gained traction as a means to successfully overcome…
Hózhó: Phone-based GDMT Initiation and Uptitration Feasible and Effective among HFrEF patients in Navajo Nation
Key Points: GDMT utilization is suboptimal among American Indian patients with HFrEF in Navajo Nation. In this pragmatic, stepped-wedge, randomized clinical trial, a telehealth intervention using telephone calls and remote…
HUDDLE: Cross-sectional study finds large gap between hypertension prevalence and awareness among former NFL athletes
Key Points: Little is known about the prevalence of cardiovascular risk factors or disease in former professional athletes. Gaps may exist between the awareness and prevalence of CVD in this…
Health 360x: Medical assistants more likely to complete training and remain in clinical research in community practices
Key Points: Research coordinators embedded in community-based practices can help ensure that underrepresented and underserved patients have equitable point-of-care access to decentralized clinical trials. This study evaluated a need-based protocol-specific…
HeLP: Behavioral interventions improve cardiac rehabilitation attendance among recently hospitalized patients with lower SES
Key Points: Low-SES patients are less likely to attend CR following hospitalization for a major cardiovascular event and are more likely to be readmitted compared to those with higher SES.…
MINT subgroup analysis: Among patients with acute MI and anemia, a restrictive transfusion strategy was associated with higher rates of death and MI at 30 days
Key Points: The MINT trial found that among patients with acute MI and anemia, those randomized to a liberal transfusion strategy had lower rates death or MI at 30 days…
Routine Assessment of Patient-Reported Health Status in Academic Clinics Did Not Improve Patient-Reported Health-Status: The PRO-HF Trial
Key Points: The latest AHA/ACC Heart Failure (HF) guidelines recommend routine assessment of patient-reported health status, but no randomized trials have analyzed its possible impact on routine HF care. This…
A Spirituality-Based Intervention Improves Blood Pressure Control and Central Hemodynamics: The FEEL Trial
Key Points: HTN is a leading cause of cardiovascular (CV) morbidity and mortality worldwide, but blood pressures remain uncontrolled worldwide. Spirituality, a comprehensive concept encompassing both personal and interpersonal factors,…
Advancing Acute MI Care in Densely Populated LMICs: Innovative Standalone Chest Pain Units for Expedited Triage and Timely Management – A Role Model for Global Healthcare Systems
Key Points: The burden of coronary artery disease (CAD) is high in South Asia, but challenges are present with time-sensitive cardiac care, as evidenced within Karachi, Pakistan (population: >23 million) …
Simultaneous Team-Based Remote Education and Medication Titration Increases Diabetes Medication Prescription Compared to a Sequential Approach: The Diabetes Remote Intervention to ImproVe Use of Evidence-based Medications (DRIVE) Study
Key Points: Despite demonstrated effectiveness of many SGLT2-inhibitors and GLP-1 agonists at improving both cardiovascular (CV) and kidney outcomes, utilization of these therapies remains low. Study investigators performed a randomized…
No Benefit of Long-Term Beta-Blockers after MI with Preserved EF: REDUCE AMI Trial
Key Points -Beta blocker therapy in patients with acute MI is the current standard of care, but we lack clinical trials testing this concept in the era of PCI and…
TACT2: Chelation therapy with EDTA does not improve cardiovascular outcomes in post-MI patients with diabetes
Key Points: EDTA is a highly effective chelator of the ubiquitous pollutants lead and cadmium, both of which are associated with elevated cardiovascular risk. The first TACT study found that…
ULTIMATE-DAPT: De-escalating to ticagrelor alone after 1 month reduced bleeding without an increase in ischemic events compared to continuous DAPT through 1 year
Key Points: The optimal time to de-escalate from DAPT to SAPT following PCI with modern DES after ACS is uncertain. The ULTIMATE-DAPT study found that transitioning from aspirin and ticagrelor…
LIBerate-HR Trial: Lerodalcibep, A Small-Binding Protein Based PCSK9 Inhibitor Administered Monthly Significantly Lowered LDL-C
Key Points - Newer cholesterol guidelines advise lower target values for LDL-C for high-risk patients, yet many patients do not reach this goal on statin therapy alone - Lerodalcibep is…
BRIDGE-TIMI 73a Trial: Olezarsen significantly reduces triglyceride levels among patients with hypertriglyceridemia and elevated CV risk
Key Points: Olezarsen is an antisense oligonucleotide which targets messenger RNA for apolipoprotein C-III (APOC3), a lipoprotein which up-regulates triglyceride levels. BRIDGE-TIMI 73a was a phase 2b randomized, placebo-controlled trial…
Mandibular Advancement Device (MAD) Therapy Non-Inferior to CPAP for Blood Pressure Reduction In OSA And High CV Risk: The CRESCENT Trial
Key Points: Hypertension (HTN) guidelines recommend treating obstructive sleep apnea (OSA) in such patients, though data on BP reduction for mandibular advancement devices (MADs) and continuous positive airway pressure (CPAP)…
Targeting Weight Loss to Personalize the Prevention of Type 2 Diabetes Mellitus
Key Points: There is uncertainty determining who is likely to develop dysglycemia and type 2 diabetes mellitus (T2DM) due to weight gain and adiposity: 80% of those with obesity do…
AEGIS-II: Apo A-I Infusions Did Not Reduce 90-Day MACE but Trended Towards Reduction in CV Death and MI
Key Points: Post-MI adverse cardiovascular events remain high despite robust evidence-based antiplatelet, statin, and anticoagulant therapy. Cholesterol efflux is impaired post-MI and has been associated with short- and long-term MACE.…