A single SC dose of Zilebesiran reduced systolic blood pressure in uncontrolled hypertension: KARDIA-2
Key Points: Zilebesiran is a subcutaneous injectable that targets hepatic angiotensinogen (AGT)…
BrigHTN: Baxdrostat, an aldosterone synthase inhibitor, showed dose-related reductions in blood pressure and safely and effectively lowers blood pressure in patients with resistant hypertension
Key Points In a Phase 2 randomized trial, baxdrostat, a highly potent…
FRESH –First-in-Class Aminopeptidase-A Inhibitor Firibastat Fails in Resistant Hypertension
Key Points Hypertension remains a major public health threat contributing significantly to…
PRECISION –Dual Endothelin Receptor Antagonist Aprocitentan Superior to Placebo in Resistant Hypertension
Key Points Despite the many drug classes available to treat hypertension, the…
The Diuretic Comparison Project (DCP): For hypertensive patients already on hydrochlorothiazide, switching to chlorthalidone does not improve outcomes
Key Points: Thiazide type diuretics are first-line medications for hypertension (HTN); while…
RADIANCE II: Endovascular ultrasound denervation met primary/secondary efficacy BP lowering endpoints at 2 months
Key Points: Endovascular ultrasound denervation (uRDN) is a potentially useful technique in…
Ultrasound Guided Renal Denervation shown to Decrease Ambulatory Blood Pressure in Patients with Resistant Hypertension: Results from the RADIANCE-HTN TRIO Trial
While renal denervation has been shown to improve blood pressure in patients…
TIPS-3 Trial: The Combination of Polypill and Aspirin Administered to Patients at Intermediate Risk Led to a Lower Incidence of Cardiovascular Events Compared With Double Placebo
A recent trial by Dr. Salim Yusuf, published in The New England Journal…
REPLACE COVID Trial: Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers Can Be Safely Continued in Patients Admitted to Hospital With COVID-19
A recent trial by Dr. Jordana B Cohen, published in The LANCET, indicated that…
100,000 Patient Meta-Analysis Shows Carotid Intima-Media Thickness Progression Can Be Used as a Surrogate Marker for Cardiovascular Risk
A recent meta-analysis of clinical trials with more than 100,000 patients has…
In a Recent Large Cohort Renin–Angiotensin–Aldosterone System Inhibitors Were Not Associated with Increased Risk of COVID-19 and Severe Illness
Medications acting on the renin-angiotensin-aldosterone system (RAAS), such as ACE inhibitors and…
A Population-Based Study Showed No Association Between COVID-19-Induced In-Hospital Death and Angiotensin-Converting–Enzyme Inhibitors and Angiotensin-Receptor Blockers Use
A recent study by Dr. Mehra, published in the New England Journal…
Population-Based Cohort Study Shows Blood Pressure Trajectories Over The Life Course Progress More Rapidly in Women Compared to Men
A new study by Dr. Hongwei, published in JAMA Cardiology, demonstrated that…
Positive Correlation Found Between Combined Life-time Exposure of Decreased LDL-C and Low Systolic BP in Lowering the Risk of Cardiovascular Disease
A recent study by Brian A. Ference et al. based on a…
HOPE 4: A Comprehensive Community-based Program Surpassing the Barriers in Improving BP Control and Associated Cardiovascular Disease Risk in 2 Middle Income Countries
Significant improvement in blood pressure control and related cardiovascular disease (CVD) risk…
11,000 Patient Study Demonstrates That Higher 24 hour and Nighttime Blood Pressure Readings Associated With Increased Risk of Cardiac Events
In an original investigation done by Dr.Wen-Yi Yang and his team, the…
Vascular Risk Factors Tied to Unhealthy Brains, Study from UK Biobank Suggests
Vascular risk factors such as smoking, hypertension, and diabetes were associated with…
1.3 Million Patient Study Shows That Even With New Lower Definition for Hypertension, Elevated Systolic and Diastolic Blood Pressure Both Independently Increase Risk of Cardiovascular Events
In a recent original cohort study done by Alexander C. Flint and…
Latest Cross-Sectional Study Links Dietary Pattern Specific Protein Biomarkers to Development of Cardiovascular Disease
According to a nationwide cross-sectional study, protein biomarkers along with specific dietary…
A Systematic Analysis Attributes Eleven Million Deaths in 2017 to Dietary Risk Factors
A systematic analysis by Dr. Ashkan Afshin and the Global Burden of…