Early, Short-Term Use of Rivaroxaban Plus DAPT Significantly Reduces Intracoronary Thrombus
Key Points: In the ARISE-ARMYDA 7 trial, 40 patients who presented with ST elevation myocardial infarction and a plan for a deferred stenting strategy were randomized to receive rivaroxaban 2.5…
Solbinsiran, a Small Interfering RNA Targeting ANGPTL3,Reduced ApoB in Patients with Mixed Dyslipidaemia : PROLONG-ANG3
Key Points: Many patients with ASCVD are on LDL-lowering therapy, but many patients with elevated TGs remain at elevated risk Solbinsiran, a novel siRNA therapy, may lower cholesterol by targeting…
Health360x.ai Successfully Implemented Decentralized Clinical Trials in Underserved Populations
Key Points: Health360x.ai is an AI-powered digital health platform designed to scale access to decentralized clinical trials (DCTs) by addressing infrastructure gaps in small and medium-sized practices. Across 35 community-based…
Coaching Intervention Did Not Increase Physical Function or Cardiac Rehabilitation Participation: MACRO
Key Points: Older adults have higher cardiovascular risk in conjunction with other comorbidities Cardiac rehab (CR) is an opportunity to improve health after major cardiovascular events, but multiple factors often…
GCVRC: Controlling Hypertension and Stopping Smoking at Midlife Associated With Greatest Gains in Additional Life-years Free of CVD
Key Points Five classic risk factors – HTN, DM, HLD, underweight/obesity, and smoking – account for 50% of the global burden of CV disease. The purpose of this global epidemiological…
0/1-Hour Algorithm Safe and Effective for Rapid Chest Pain Assessment in the ED: DROP-Asian ACS Trial
Key Takeaways: The 0/1-hour hs-cTn algorithm is safe, non-inferior to usual care, and significantly increases ED discharge rates while reducing short-term cardiac events among Asian patients presenting with chest pain.…
Routine Orbital Atherectomy Does Not Improve Outcomes vs Balloon Angioplasty for Severely Calcified Coronary Lesions: ECLIPSE Trial
Key Takeaways: Orbital atherectomy as a routine lesion preparation strategy prior to stenting did not reduce clinical events or improve stent expansion compared to balloon angioplasty alone for severely calcified…
AI QCT Coronary Plaque Features More Predictive in Women: CONFIRM2 Registry
Key Points: Women are underdiagnosed and undertreated for CAD, despite higher prevalence of non-obstructive CAD, leading to worse outcomes Using AI-enhanced assessment of coronary artery plaque characteristics, investigators suggest better…
AI-Quantitative CT Coronary Plaque Features Indicate Higher Relative CV Risk in Women: CONFIRM2 Registry
Key Takeaways: AI-based quantitative coronary plaque assessments significantly improve risk prediction for cardiovascular events in women compared to traditional clinical risk scores. Although women had lower absolute plaque burden, the…
First-in-Human Gene Therapy (TN-201) Shows Promising Results in MYBPC3-Associated HCM
Key Takeaways: TN-201, a first-in-class gene therapy, was well tolerated and showed stable cardiac gene expression, improved biomarkers, and symptom relief in patients with severe MYBPC3-associated hypertrophic cardiomyopathy. All treated…
Artificial Intelligence Enables Novices to Perform Diagnostic-Quality Echocardiography: HeartFocus Study
Key Takeaways: AI-guided echocardiography enables novice users to obtain diagnostic-quality cardiac images comparable to expert sonographers, achieving perfect diagnostic-quality rates (100%) for primary cardiac parameters. AI-assisted echocardiography shows rapid adoption…
Survival After Sudden Cardiac Arrest Improves in Young Athletes, but Racial Disparities Persist
Key Takeaways: Survival from sudden cardiac arrest among young competitive athletes increased significantly from 38% to 66% over the last decade, driven by enhanced emergency preparedness and improved access to…
ALPACA Trial – Lepodisiran Significantly Reduces Lipoprotein(a) in Phase II Trial
Key Points Elevated lipoprotein(a) is associated with incident atherosclerotic cardiovascular disease and aortic stenosis The ALPACA trial randomized 320 patients with a serum lipoprotein(a) concentration ≥175 nmol/L in 1:2:2:2:2 ratio…
TRILUMINATE– Transcatheter edge-to-edge repair reduces TR severity and HF Hospitalizations
Key Points The TRILUMINATE Pivotal trial previously reported that transcatheter edge-to-edge repair (TEER) improved quality-of-life compared to medical therapy alone for severe, symptomatic tricuspid regurgitation. The trial did not observe…
PURSUIT Trial – Dose Dependent Reduction in LDL-C with AZD0780, Oral PCSK9 inhibitor
Key Points The majority of ASCVD patients fail to achieve guideline endorsed LDL targets The PURSUIT trial randomized 428 patients in a 1:1:1:1 ratio to receive oral AZD0780 1, 3,…
Comparison Of Angiography-Derived FFR to IVUS in PCI: FLAVOUR II
Key Points: In the FLAVOUR II trial, 1839 patients with angiographically-significant coronary artery disease were randomized to receive angiography-derived fractional flow reserve (AngioFFR) guided vs. intravascular ultrasound (IVUS) guided percutaneous…
No Difference with Mobile Integrated Health vs A Transitions Of Care Coordinator in HF: MIGHTy-Heart
Key Points: In the MIGHT-y Heart Trial, 2,003 patients who were hospitalized for heart failure across 11 hospitals in New York City were randomized to receive post-discharge follow-up via a…
Electronic Provider Notification Significantly Improved Quality of Care Delivered for Severe AS: DETECT AS
Key Points: In the DETECT AS trial, 285 providers for 939 patients with severe aortic stenosis were randomized to receive an electronic provider notification (EPN) notifying the provider of the…
Routine Cerebral Embolic Protection Did Not Reduce Incidence of Peri-procedural Stroke in TAVI: BHF PROTECT-TAVI
Key Points: Stroke remains one of the most feared complications of transcatheter aortic valve implantation (TAVI), prompting interest in cerebral embolic protection (CEP) devices. The BHF PROTECT-TAVI trial studied the…
TAVR with Trilogy System Safe and Effective for Aortic Regurgitation: Updated Results from ALIGN-AR
Key Points: Transcatheter aortic valve replacement for aortic valve disease has largely focused on those with aortic stenosis. In pure, native-valve aortic regurgitation, there remains a paucity of options beyond…