REPRIEVE Substudy: Pitavastatin reduces non-calcified coronary plaque in people with HIV
Key Points The REPRIEVE trial recently demonstrated that pitavastatin reduced major adverse cardiovascular events by 35% among individuals with HIV at low-moderate... Read more.
NOAH-AFNET 6: AHRE>24 hours associated with low stroke risk but more likely to develop AF later
Key Points This pre-specific subanalysis of NOAH-AFNET 6 found that those with long lasting atrial high rate episodes >24 hours were more likely to develop atrial... Read more.
ARTESIA: Apixaban reduces the risk of stroke in subclinical AF, with an increase in major non-fatal bleeding
Key Points This randomized trial of 4012 patients (median age ~77, mean CHA2DS2VASC ~4, ~65% male) with an implanted pacemaker, defibrillator, or cardiac monitor... Read more.
Novel siRNA targeting therapy lepodisiran results in a dose-dependent and sustained reduction in Lipoprotein(a)
Key Points: There are currently no approved targeted therapies for the reduction of Lp(a). In this Phase I study, a novel siRNA therapy (lepodisiran) was tested... Read more.
ARIES-HM3: Aspirin avoidance Is safe and reduces bleeding events in patients with HM3 LVAD on VKA
Key Points: Since the advent of novel HeartMate 3 LVAD technology with lower thrombotic risk, the clinical utility of continuing to add aspirin to the antithrombotic... Read more.
POCKET-COST-HF: Comprehensive Cost Disclosure improves cost-informed decision making
Key Points: Out-of-pocket costs for GDMT in HFrEF have risen substantially with the advent of novel effective therapies. However, there is limited information regarding... Read more.
Dietary sodium reduction significantly lowered BP in middle-aged to elderly adults
Key Points: Daily sodium intake remains high (on average ~3,500 mg/day), despite recommendations from the AHA and WHO to limit sodium intake to around 2,000 mg/day. ... Read more.
TEAMMATE Trial: Everolimus with Low-Dose Tacrolimus to Prevent Rejection in Children after Cardiac Transplantation
Key Points This was the first randomized trial to evaluate the safety and efficacy of everolimus and low-dose tacrolimus in pediatric heart transplant recipients.... Read more.
Percutaneous Coronary Intervention Improved Symptoms in Stable Angina: ORBITA-2 trial
Key points: PCI is often performed for chronic stable angina, but current evidence is unclear to what extent the benefit is physiologic vs placebo This trial compared... Read more.
MINT Trial – In Patients with MI and Anemia, Liberal Blood Transfusion not Significantly Different to Restrictive Strategy in Reducing Death or MI
Key Points Anemia is common among individuals with acute myocardial infarction, however, transfusion thresholds and targets remain uncertain. The MINT trial randomized... Read more.