Chronic Red Meat Consumption Associated With Increased TMAO Concentrations
A recent study published in the European Heart Journal showed that chronic red meat consumption is associated with increased serum and urine concentrations of trimethylamine N-oxide (TMAO), a metabolite associated…
Left Main PCI With DES Versus CABG: PCI Shows Similar Rates of Death, But a Higher Rate of Target-Vessel Revascularization at Ten Years
A study by Duk-Woo Park et al. has shown that in patients with significant left main coronary artery (LMCA) disease, as compared with CABG, PCI showed similar rates of death…
Lesser Training In Amateur Marathon Runners Can Lead to Raised Troponins
A recent article published in Circulation by John Del Coso and his team demonstrated that the cardiac stress during a marathon is higher than the cardiac stress produced by competing in…
Drug-Coated Balloon Outperforms Percutaneous Transluminal Angioplasty in Femoropopliteal Disease
A study conducted by Yongle Xu et al. demonstrated that the superiority of Drug-Coated Balloon (DCB) versus percutaneous transluminal angioplasty (PTA) in the efficacy of femoropopliteal artery disease (FPAD) treatment…
Top-Ranked Hospitals Have Better Survival Rates, But Not Necessarily A Lower Risk of Readmission
Cardiology patients treated in hospitals at the top of U.S. News & World Report rankings had better survival rates, but not necessarily less risk of readmission, researchers found. This study by Wang…
Endocarditis Persists Five Years After Transcatheter Deployment of Melody Valve Prosthesis in Pulmonary Position
The results of a study conducted by Doff B. McElhinney and his colleagues published in JACC showed that endocarditis is an important adverse outcome following Transcatheter Pulmonary Valve Replacement (TVPR)…
Does Race/Ethnicity Affect Oral Anticoagulant Use in Patients With Atrial Fibrillation?
A study by Essien and his colleagues published in JAMA aimed to determine if there were racial/ethnic differences in the use of oral anticoagulants, particularly direct-acting oral anticoagulants (DOACs), in…
New TAVR Insights: Survival Advantage of TAVR Over SAVR Not Sustained At Five Years, Severe Prosthesis-Patient Mismatch Not Benign Following TAVR
The 5-year outcomes of a trial conducted by Gleason et al. published in JACC demonstrated a similar safety profile, functional recovery, and freedom from severe structural valve deterioration (SVD) for…
Coronary Physiology Beyond Coronary Flow Reserve: A Giant Leap in the Understanding of Coronary Microvascular Disease
In a JACC State-of-the-Art Review by Dr. Lance Gould and his colleagues at UTHealth, Houston, Texas, the pathophysiology of Coronary microvascular disease (CMD) was summarized and an update was provided…
NT-ProBNP-Guided Medical Therapy Failed To Show Superiority Compared To Usual Care In HFrEF
Results of a multi-center, randomized clinical trial which enrolled 894 patients with heart failure (HF) with reduced ejection fraction (EF ≤40%) published in the most recent issue of the Journal…
Diagnosis of Frailty in a Patient with Acute Myocardial Infarction Helps Personalize an Approach to Optimize Outcomes
In a report in this issue of the JACC: Cardiovascular Interventions, Dr. John A Dodson and his colleagues from the New York University School of Medicine reported that frail patients…
N- acetylcysteine and Intravenous Sodium Bicarbonate Infusion in the Prevention of Contrast Associated Kidney Injury: A Cautionary Tale
A study published in JACC Cardiovascular Interventions has shown that among patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI), there was no benefit of IV sodium bicarbonate…
Workplace Bullying and Violence Might be New, Potentially Modifiable Cardiovascular Risk Factors
A European study has revealed that bullying and violence are common at workplaces and those exposed to such stressors are at higher risk of cardiovascular disease (CVD). Psychosocial cardiovascular risk factors…
Mechanistic Study Delves Into Heart Failure Benefits Noted With Empagliflozin
The EMPA-HEART trial showed that empagliflozin resulted in beneficial effects on left ventricular remodeling at 6 months among patients with type 2 diabetes mellitus and stable coronary artery disease (CAD)…
TRED-HF: Tread With Caution While Withdrawing Heart Failure Medication in Recovered Dilated Cardiomyopathy
The results of the TRED-HF trial published in The Lancet showed that withdrawal of heart failure medications among patients with dilated cardiomyopathy (DCM) who had recovered their LV function resulted…
Does Low Dose Methotrexate Prevent Athersclerotic Events in Patients?
A randomized clinical trial that was conducted by Paul M Ridker et al. and published in NEJM showed that there was no meaningful association between low dose methotrexate (MTX) administration and a…
Canakinumab: A New Hope for Post MI Patients with Increased hsCRP in the Prevention of Heart Failure
Canakinumab (an IL-B inhibitor) is associated with decreased heart failure (HF) hospitalizations and the composite of heart failure hospitalization and heart-failure related mortality in patients with a history of myocardial…
Superior Efficacy of Sacubitril-Valsartan Compared to Enalapril for lowering NT Pro-BNP in Patients Hospitalized for HFrEF
Results from a multi-center, randomized, double-blind, double dummy, parallel group clinical trial which enrolled 881 patients with heart failure (HF) with reduced ejection fraction (HFrEF-left ventricular ejection fraction of 40%…
Dapaglifozin ‘DECLARED’ Effective in the Reduction of Heart Failure Hospitalizations in Diabetic Population
The DECLARE–TIMI 58 trial, published in the New England Journal of Medicine and presented at AHA 2018 showed that in patients with type 2 diabetes who had or were at…