REC-CAGEFREE I: Drug Coated Balloon Fails To Achieve Non-Inferiority vs DES For De Novo Coronary Lesions
Key Points Drug-eluting stents are the standard of care for percutaneous coronary…
Plozasiran Lowered Triglyceride Levels and Pancreatitis in Persistent Chylomicronemia: PALISADE
Key Points: Familial chylomicronemia syndrome (FCS) is a clinically or genetically defined…
Bailout GP IIb/IIIa inhibition in AMI with angiographic MVO failed to reduce the primary endpoint infarct size but decreased CMR-derived MVO: The REVERSE-FLOW trial
Key Points: Though primary PCI for coronary obstruction is first-line therapy in…
AZALEA-TIMI 71 Sub-study: Periprocedural Bleeding Risk Very Low and Similar With Long-acting Factor XI Inhibitor Abelacimab vs Rivaroxaban
Key Points: Factor XI inhibitors have the potential to reduce thromboembolic events…
De-escalation to Ticagrelor Monotherapy Beneficial in Ischemic Events and Bleeding vs 12 months of DAPT: a Systematic Review and Individual Patient-Level Meta-analysis
KEY POINTS: Ticagrelor monotherapy was found to be non-inferior to 12 months…
Microvascular Resistance Reserve as a Potential Predictor of Angina in Moderate Coronary Stenoses.
Key Points: The Microvascular Resistance Reserve (MRR), a novel measurement, assess the…
Functional Improvement of non-infarcT relaTed coronary artery stenosis by Extensive LDL-C Reduction with a PCSK9 Antibody (FITTER)
Key Points: Adverse cardiovascular events can still occur from atherosclerotic events in…
A Low-Dose Triple Single-Pill Combination Effective at Lowering Blood Pressure
Key Points: A single pill containing low doses of three different medicines…
OCCUPI: Optical Coherence Tomography (OCT) Outperforms Conventional Angiography in Guiding Revascularization for Complex Coronary Lesions
Key Points: In all-comer populations, coronary imaging guidance shows superior outcomes compared…
EARTH STEMI: Complete Revascularization Reduces Ischemic Events up to 4 years Among Older Patients with STEMI with Multivessel Disease
Key Points: Approximately 50% of patients with STEMI have multivessel disease but…
SENIOR-RITA: In Elderly Patients With NSTEMI, An Invasive Strategy Improved Clinical Outcomes Compared To Optimal Medical Therapy Alone
Key Points: Many older patients with NSTEMI do not receive coronary angiography…
GUARD–AF: Wearable ECG Patch Increased the Yield of AF Diagnosis
Key Points: A 14-day heart rhythm monitoring with a wearable patch in…
OCEANIC AF – Asundexian is inferior to apixaban for stroke prevention in patients with atrial fibrillation
Key Points: Factor XIa inhibition may reduce stroke risk while causing bleeding.…
Edoxaban Monotherapy Associated with Better Net Clinical Benefit than Edoxaban Plus Single Antiplatelet in Patients with AF and Stable CAD: EPIC-CAD
Key Points: In patients with stable coronary artery disease and atrial fibrillation,…
IVORY FINALE: Low-Dose IL-2 Reduces Arterial Inflammation after ACS
Key Points: While inflammation is critical to the pathogenesis of atherosclerosis, few…
QUADRO – Quadruple Polypill More Effective In Lowering Blood Pressure Than Taking Three Separate Medications in Resistant Hypertension
Key Points: Treatment of resistant hypertension often involves at least three or…
A Single Combined Measure Of hsCRP, LDL-C, And Lp(A) Predicts Incident CV Events Over 30 Years Among Women’s Health Study Participants
Key Points: While drug trials evaluate the short-term cardiovascular risk associated with…
ASSURE DES: No Difference In Ischemic Events If Aspirin Is Interrupted Or Continued In Patients With DES Undergoing Non-Cardiac Surgery
Key Points: Anti-platelet therapy after coronary drug eluting stent (DES) placement reduces…
Morning vs. evening dosing of blood pressure meds: No differences in outcomes or safety for either community-dwelling adults or frail nursing home residents
Key Points: Blood pressure follows a circadian rhythm, peaking after waking and…
NOTION-3: Revascularization in Patients Undergoing TAVI Associated with Lower Risk of MACE vs Conservative Treatment
Key Points: The NOTION-3 trial found that FFR-guided revascularization with PCI in…