Pulsed Field Ablation Effective to treat Paroxysmal and Persistent AF: The PULSED AF Pivotal Trial
Key Points: - Pulsed field ablation (PFA) is a novel ablation technology which utilizes electrical pulses to deliver irreversible electroporation and induce thermal cardiac cell death and has shown high…
COORDINATE-Diabetes – A Coordinated, Multifaceted Intervention Increases Prescription of Evidence-based Therapies for Adults with T2D and CV Disease
Key Points Evidence-based therapies that reduce cardiovascular risk remain underused among individuals with type 2 diabetes and cardiovascular disease The COORDINATE-Diabetes cluster-randomized clinical trial included 43 cardiology clinics treating individuals…
The GCCF Project: Remote monitoring reduces cardiology’s carbon footprint
Key Points Cardiac device monitoring is a repetitive, long term activity that can be resource intensive. The Global Cardiovascular Carbon Footprint (GCCF) project sought to evaluate the extent to which…
Elevated hs-cTnL levels precede and predict pre-eclampsia
Key Points: There have been limited data regarding the biomarkers that may predict the development and severity of preeclampsia. hs-cTnI was significantly elevated in pregnant women who would later develop…
TEER for degenerative MR Safe, Effective: a real world analysis using the STS/ACC TVT registry
Key Points While transcatheter edge-to-edge repair (TEER) is FDA approved for treatment of degenerative mitral regurgitation (MR) in patients at high surgical risk, outcomes in this population are not well…
STREAM-2 Trial: Half-dose TNK + PCI Provides Effective reperfusion In Elderly STEMI Patients
Key Points: Pharmaco-invasive (PI) strategy with half-dose tenecteplase (TNK) is compared to routine primary percutaneous coronary intervention (pPCI) in STEMI patients over 60 years of age who presented within 3…
Electronically Delivered Nudges Increase Influenza Vaccination Uptake: The NUDGE-FLU Trial
Key Points Despite the proven benefits of annual influenza (flu) vaccination among patients with cardiovascular disease (CVD), uptake remains suboptimal. The NUDGE-FLU implementation trial randomized all Danish citizens ages 65…
RAPID HF: Rate-adaptive atrial pacing for HFpEF not ready for prime time
Key Points Over half of the patients with HFpEF suffer from exercise intolerance, which may be often due to inability to augment heart rate (HR). As such, rate-adaptive atrial pacing…
PCDS Statin: Automated reminders increase statin use in ASCVD patients
Key Points Despite guideline recommendations, both statin use overall and high intensity statin (HIS) use specifically remains low in patients with established atherosclerotic cardiovascular disease (ASCVD). Both therapeutic inertia (TI)…
ACCESS: Eliminating chronic disease medication co-payments for low income elderly adults improved adherence but did not change clinical outcomes
Key Points Cost related medication non-adherence is a common problem among patients with cardiovascular disease and is associated with poor clinical outcomes. Whether eliminating co-payments for a large number of…
Using Causal A.I. to Translate Polygenic Risk for Coronary Artery Disease into Clinically Actionable Information: How much does LDL or SBP need to be lowered to overcome inherited polygenic risk?
Key Points: Polygenic scores (PGS) give insights into a patient’s inherited risk for coronary artery disease (CAD) but it is unclear how this information should inform clinical care. Participants in…
Minimally invasive thoracoscopically-guided right mini thoracotomy for mitral valve repair is a safe and effective alternative to conventional sternotomy
Key points : Mitral valve surgery via sternotomy is associated with significant disadvantages, including an increased risk of bleeding, difficult valve access due to the incision's location, and a 2-3%…
BETTER CARE-HF: EHR-embedded alert increased MRA prescription in AMBULATORY HFrEF patients
Key Points Many patients with heart failure with reduced ejection fraction (HFrEF) are not on optimal guideline directed medical therapy (GDMT), especially mineralocorticoid receptor antagonists (MRAs), despite their strong evidence…
TAVR at 3 years showed durable benefits vs surgery: the Evolut Low Risk Trial
Key Points Both transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) procedures offer options for intervention in patients with aortic stenosis High-surgical risk has guided the use…
TRILUMINATE: Tri-Clip reduces tricuspid regurgitation and improves quality of life at one year
Key Points: There have been limited data examining the safety and efficacy of transcatheter tricuspid repair systems. In the TRILUMINATE study, Tri-Clip was compared against medical therapy in patients with…
FLAME: FlowTriever use for PE associated with decreased in-hospital adverse outcomes
Key Points: Mortality in high-risk PE remains unacceptably high (25%) despite advances in medical and interventional therapies. The FLAME study was a prospective, multi-center non-randomized observational study to describe the…
Intravascular Imaging-Guiding PCI in Complex Coronary Lesions Linked to Better Outcomes: The RENOVATE-COMPLEX-PCI Study
Key Points: Intravascular imaging-guided PCI shows promise in improving outcomes for patients with complex coronary artery lesions, with a 36% reduction on the primary outcome (composite of cardiac death, target…
TARGET Trial: On-site CT-FFR Feasible and Effective in stable CAD
Key points: The TARGET trial is the first randomized trial designed to assess the impact of an on-site CT-FFR strategy using machine learning compared to standard care in patients with…
BIOVASC Trial: Immediate complete revascularization non-inferior to staged complete in MVD ACS patients
Key Points: Complete revascularization is recommended in patients with multivessel CAD who present with ACS without cardiogenic shock, but the optimal timing of non-culprit lesion revascularization is unknown. The BIOVASC…
HALO – Baxdrostat Fails to Beat Placebo for Blood Pressure Reduction in Uncontrolled Hypertension
Key Points Baxdrostat, a highly selective aldosterone synthase inhibitor, reduced systolic blood pressure as compared with placebo among patients with resistant hypertension in the BrigHTN trial. Efficacy and safety data…