New 1,500 Patient Study Demonstrates Favorable 1-Year Mortality Rate in Mitral Valve-In-Valve Implantation in Patients With Failed Mitral Valve Surgery
The results of a combined analysis of the STS/ACC/TVT Registry and the Centers for Medicare and Medicare Services (CMS) were presented by Dr. Mayra Guerrero, an interventional cardiologist and Professor…
SCOPE I: ACURATE Neo (Self-Expanding TAVR System) Struggles to Have An Edge On SAPIEN 3 (Balloon-Expandable TAVR System)
Results of a randomized trial presented at TCT 2019 and simultaneously published in The Lancet, showed that TAVR with the self-expanding ACURATE neo (Boston Scientific) did not meet non-inferiority compared…
Novel Subcutaneously Administered GpIIb/IIIa Inhibitor (RUC-4) Exhibits Promising Potential As The First Point-of-Contact Therapy of STEMI
Results of a new ongoing phase 1 study, presented at Transcatheter Cardiovascular Therapeutics (TCT) 2019 San Francisco, showed that as a first point-of-contact therapy for ST-elevation myocardial infarction (STEMI), a…
TWILIGHT Trial: Single Anti-Platelet Therapy (SAPT) Using Ticagrelor Reduces Bleeding Risk And Preserves Ischemia Prevention Post-PCI
A randomized, double-blinded, placebo-controlled trial which enrolled 7119 high risk patients with coronary artery disease who had undergone recent percutaneous coronary intervention (PCI) has shown that, after 3 months of…
New Study Shows Levels of Circulating Cardiovascular Biomarkers Are Different in Men and Women
A study led by Dr. Emily Lau published in the Journal of the American College of Cardiology showed that there were significant differences in circulating biomarkers in men and women.…
EWTOPIA 75 Trial: Lowering LDL-Cholesterol with Ezetimibe Prevents Cardiovascular Events in the Elderly
Individuals older than 75 years treated with ezetimibe had a significantly lower risk of atherosclerotic cardiovascular events over 4 years compared with standard care, according to the results of the…
Positive Correlation Found Between Combined Life-time Exposure of Decreased LDL-C and Low Systolic BP in Lowering the Risk of Cardiovascular Disease
A recent study by Brian A. Ference et al. based on a UK Biobank study, published in JAMA, has shown that life-time exposure to decreased low-density lipoprotein cholesterol (LDL-C) levels…
Meta-analysis Shows Reduced 1-Year Mortality with TAVR in Low-Risk Severe AS Patients
In a meta-analysis of RCTs comparing TAVR (Transcatheter Aortic Valve Replacement) versus SAVR (Surgical Aortic Valve Replacement) in low-risk patients with severe AS, TAVR was associated with a significantly lower…
REVELATION Trial: Paclitaxel-Coated Balloon Angioplasty is Non-Inferior To The Routinely Conducted Drug-Eluting Stenting in STEMI Patients
According to a recent study based on the REVELATION Trial, conducted by Nicola S. Vos et al. and published in JACC, Paclitaxel-coated balloon angioplasty was documented to be non-inferior to…
HOPE 4: A Comprehensive Community-based Program Surpassing the Barriers in Improving BP Control and Associated Cardiovascular Disease Risk in 2 Middle Income Countries
Significant improvement in blood pressure control and related cardiovascular disease (CVD) risk is seen as a result of a potentially effective and pragmatic comprehensive model of care conducted as HOPE…
No significant association between myocardial viability & long-term survival benefit of CABG in patients with ischemic cardiomyopathy
According to a new study published in The New England Journal of Medicine (NEJM) based on a 10-year follow-up STICH trial, no association was found between myocardial viability as a…
ADRIFT Trial: Low-Dose Rivaroxaban is Superior to Dual Antiplatelet Therapy for Controlling Thrombin Generation after Left Atrial Appendage Closure in Atrial Fibrillation Patients
According to the results of Assessment of Dual Antiplatelet Therapy Versus Rivaroxaban in Atrial Fibrillation Treated with Left Atrial Appendage Closure (ADRIFT) trial, recently presented at the European Society of…
Dual Anti-thrombotic Therapy Safe For Patients with Atrial Fibrillation and Recent PCI:ENTRUST-AF PCI
Results from a phase-IIIb, open-label, multi-center, randomized clinical trial comparing the safety of dual anti-thrombotic therapy (DAT) with triple anti-thrombotic therapy (TAT) for patients with atrial fibrillation who have undergone…
SYNTAXES Study: No Significant Difference In All-Cause Death At 10 Years Between PCI and CABG
A follow-up of a multicenter, randomized controlled trial, the results of which were debuted at the European Society of Cardiology (ESC) Congress 2019, has shown that at 10 years, no…
PolyIran Trial: Polypill Prevents Cardiovascular Events
A four-component polypill, including aspirin, atorvastatin, hydrochlorothiazide, and enalapril or valsartan, effectively reduced major cardiovascular events in a real-life setting study. The results of the PolyIran trial by Roshandel G. et…
Population Based Cohort Study: With or Without AFib, CHA₂DS₂-VASc Score is a Sensitive Predictor and Stratifies the Risk of MACCE
Giulia Renda et al. recently published in the European Journal of Preventive Cardiology that the CHA2DS2-VASc score is a sensitive measure of predicting new-onset atrial fibrillation (AF) and adverse outcomes…
CLIMA Registry: OCT-Defined Plaque Morphology Links to Major Coronary Events
Data from CLIMA registry shows that simultaneous presence of four optical coherence tomography (OCT) plaque vulnerability features are associated with a seven-fold increased risk of future major coronary events. The…
International Ongoing Study Finds Low Prevalence of PE in Patients Presenting to the ER with First Time Syncopal Episode
In an ongoing diagnostic multicentric prospective study being conducted to evaluate and improve the management of patients in the emergency room (ER) presenting with syncope, an analysis was done to…
New Study Shows Elevated Levels of Troponin After Exercise Associated with Increased Rate of Cardiovascular Events
A study led by Dr. Vincent Aengevaeren, published in Circulation, showed that an elevated exercise-induced troponin I was associated with an increased risk of mortality and cardiovascular events in older…
Novel Physiology-Based Method of Estimating Myocardial Ischemic Burden
Murai et al. devised a novel physiology-based method of estimating the amount of myocardium subtended by coronary stenosis, which is feasible and can be performed in the catheterization laboratory with…