TIM-HF2 Trial: Morbidity and Mortality Benefit of Remote Telemedical Interventional Management In Heart Failure No Longer Observed 1 Year After End of Trial​
The positive effect of the remote patient management (RPM) intervention on morbidity and mortality, seen in the Telemedical Interventional Management in Heart Failure II (TIM-HF2) trial was no longer observed…
Patients with Out-Of-Hospital Cardiac Arrest Treated at Teaching Hospitals Are More Likely to Survive to 30 Days, Compared with Non-Teaching Hospitals
In a large population-based study, a significant and sustained survival benefit was observed in patients with out-of-hospital cardiac arrest treated at teaching hospitals. The report of the study led by…
Study Shows High-Intensity Statin Associated With Low Risk of Death, Stroke, ACS or Bleeding As Compared to Low to Moderate Intensity Statins or No Statins
Statins, especially high-intensity statins, could reduce the risk of a composite of death, stroke, acute coronary syndrome, or major bleeding as compared to a placebo in patients with acute ischemic…
Severe Coronary Calcification Might Delay Healing Following Implantation of Newer-Generation Drug-Eluting Stents
In an autopsy-based, histopathological analysis of stented coronary lesions, severe calcification was an independent risk factor for delayed strut coverage and healing after newer-generation DES. The report of the study…
Lower Levels of Circulating Progenitor Cells Associated with Increased Risk of Myocardial Infarction and Death In Patients with Stable Coronary Artery Disease
In patients with stable coronary artery disease, a decrease in circulating progenitor cell count during exercise is associated with worse disease prognosis compared to the presence of stress-induced myocardial ischemia.…
Study Suggests Coronary Microvascular Dysfunction and Not Glomerular Filtration Rate Associated with Abnormal Cardiac Mechanics and Worse Clinical Outcomes in Patients with Chronic Kidney Disease
A study led by Dr. Navakaranbir Bajaj published in Circulation showed that coronary microvascular dysfunction, but not estimated glomerular filtration rate was associated with abnormal cardiac mechanics and an increased…
Three Million Patient Study Shows Patients With Cancer At Higher Risk of Dying from Cardiovascular Disease As Compared to the General Population
A study led by Dr. Kathleen Sturgeon published in the European Heart Journal showed that in patients diagnosed with cancer, the majority of cardiovascular deaths in the United States occur…
One in Eight Patients with Atherosclerotic Cardiac Disease Experience Cost-Related Medication Nonadherence
One in eight patients with atherosclerotic cardiovascular disease reports medication nonadherence due to cost, according to a nationally representative survey of more than 14,000 US adults. The findings of the…
COMPLETE Trial OCT Substudy: Non-Culprit Lesions with Vulnerable Plaque Morphology Found In Half of Patients with STEMI and Multivessel Disease
The results of the COMPLETE Optical Coherence Tomography Substudy were presented by Dr. Natalia Pinilla-Echeverri at the American Heart Association 2019 meeting. The substudy found that in patients with an…
Interim Results of The EVAPORATE Trial Indicate No Change in Low Attenuation Plaque Volume But A Reduction in Total Plaque Volume Following Treatment with Icosapent Ethyl
The interim results of EVAPORATE trial, a study on the effect of Icosapent Ethyl on coronary plaque progression in statin-treated patients with elevated Triglyceride (TG) level (200-499mg/dl), were presented by…
Intensive LDL Lowering With a Goal of < 70mg/dl Is Superior to Moderate Lowering for Secondary Prevention of Ischemic Stroke Patients
A randomized parallel-group trial comparing intensive LDL-C lowering to modest lowering for prevention of major adverse cardiovascular events (MACE) in patients with recent ischemic stroke in the setting of atherosclerosis…
ISCHEMIA CKD: No Difference In Outcomes Between Medical and Invasive Approaches to Ischemia in Patients with End Stage Renal Disease
The results of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches - Chronic Kidney Disease were presented by Dr. Sripal Bangalore at the American Heart Association…
GALILEO-4D: Rivaroxaban-Aspirin Based Anti-Thrombotic Therapy Post-TAVR Protects From Valve Leaflet Motion Abnormalities
An expanded analysis of 231 patients from the GALILEO trial comparing rivaroxaban-aspirin based anti-thrombotic therapy with clopidogrel-aspirin based dual anti-platelet therapy post transcatheter aortic valve replacement (TAVR), has shown that…
DAPA-HF: Dapagliflozin Improves Heart Failure Outcomes in Patients With HFrEF Regardless of Diabetic Status
Dr. John McMurray presented the results of the DAPA-HF trial at the American Heart Association 2019 Meeting. The study, which was published in the New England Journal of Medicine, showed…
BETonMACE: Trial Shows Novel BET Protein Inhibitor Apabetalone Is Safe and Could Potentially Be Used To Improve Cardiovascular Outcomes
During the American Heart Association 2019 meeting, Dr. Kosh Ray presented the results of the BETonMACE trial. Dr. Ray and his teams showed apabetalone, a BET protein inhibitor was safe…
Phase 1 Trial Shows RUC-4 (A Novel Subcutaneous GPIIb/IIIa Inhibitor) Achieves Safe, Rapid and Effective Platelet Inhibition
The results of a phase 1 trial that evaluated the safety of RUC-4, a novel subcutaneous GPIIb/IIIa inhibitor, were presented by Dr. Dean Kereiakes at the American Heart Association 2019…
GALILEO: Rivaroxaban Based Anti-thrombotic Strategy Associated with Increased Risk of Death or Thromboembolic Events and Bleeding Compared to Antiplatelet Based Strategy in Patients with TAVR
The results of the GALILEO trial were presented by Dr. George Dangas at the American Heart Association 2019 meeting. The trial, which was stopped early, showed that in patients with…
ISCHEMIA: No Reduction in Cardiovascular Event in Patients with Stable Coronary Artery Disease Who Undergo Invasive Therapy
The results of the ISCHEMIA trial were presented by Dr. Judith Hochman at the American Heart Association 2019 meeting. The study demonstrated that in stable patients, there was no difference…
COLCOT: Colchicine Reduced Cardiovascular Events in Patients with Recent Myocardial Infarction
The results of the COLCOT trial were presented by Dr. Jean-Claude Tardif at the American Heart Association 2019 conference and published in the New England Journal of Medicine. The study…
Enhanced Vasospasm And Reduced Vasodilator Function Linked To Worse Outcomes In Patients With Non-Obstructive Coronary Arteries
A single center study that included 187 patients who presented with angina-like chest pain and nonobstructive coronary arteries on diagnostic angiography, has shown that co-existence of high microvascular resistance index…