OPTION –Indobufen is Noninferior to Aspirin After Coronary Drug-Eluting Stent Implantation
Key Points: Indobufen, a platelet aggregation inhibitor, has been shown to be a shorter acting antiplatelet in comparison to aspirin. However, it has not been studied... Read more.
PRECISE–A precision diagnostic strategy in patients with suspected CAD improves outcomes
Key Points: There is substantial heterogeneity in the use of different non-invasive and invasive modalities for CAD risk stratification; however, there limited is... Read more.
PRO-HF Sub-Study: Routine KCCQ-12 assessments in HF improves accuracy of provider assessment of patient health status.
Key Points Clinicians estimate heart failure (HF) health status using New York Heart Association (NYHA) class; however, this is often discordant with patient-reported... Read more.
RAPCO: Radial artery grafting is superior to both RITA and SVG in patients undergoing CABG
Key Points: Recent guidelines have supported the use of arterial grafts over venous grafts in coronary artery bypass grafting (CABG), but there has yet to be a single... Read more.
ECMO-CS: Early ECMO Does not Improve Outcomes in Severe Cardiogenic Shock
Key Points: ECMO has been used as a salvage strategy in severe cardiogenic shock. However, it is unclear whether immediate ECMO initiation is superior to an initial... Read more.
CTS-AMI: Tongxinluo (TXL) improves CV outcomes in acute STEMI
Key Points: Tongxinluo (TXL) is a traditional Chinese medicine with endothelial-protective effects which has been used for angina and stroke prevention in China.... Read more.
IRONMAN: Intravenous Ferric Derisomaltose did not not meet primary endpoint in HFrEF
Key Points: Iron deficiency is common and a poor prognostic feature in patients with heart failure. However, while iron infusion has improved symptoms in patients... Read more.
COACH – A Patient-Risk Based Health System Intervention for Acute Heart Failure Care: The Comparison of Outcomes and Access to Care for Heart Failure (COACH) Trial
Key Points: HF patients frequently present to the ED for acute exacerbations, and the decision whether to discharge, observe, or admit these patients can be complex.... Read more.
First-in-Human in vivo Crispr/Cas9 Editing of the TTR Gene by NTLA-2001 in patients with Transthyretin Amyloid Cardiomyopathy
Key Points: Transthyretin Amyloidosis (ATTR) is a highly morbid and often fatal cause of cardiomyopathy. Existing therapies targeting TTR protein reduction have... Read more.
The Diuretic Comparison Project (DCP): For hypertensive patients already on hydrochlorothiazide, switching to chlorthalidone does not improve outcomes
Key Points: Thiazide type diuretics are first-line medications for hypertension (HTN); while chlorthalidone (CTD) has been shown to lower blood pressure to a greater... Read more.