First-in-human Trial of CRISPR Gene-editing ANGPTL3 Safely Lowered Cholesterol and Triglycerides
Key Points: CTX310 is a first-in-class in vivo CRISPR-Cas9 therapy designed to…
POLY-HF: Polypill for HFrEF Shows Promise in Reducing Medication Burden Among Underserved Patients
Key Points: Patients with heart failure with reduced ejection fraction (HFrEF) often…
Family-Based Intervention Reduced Blood Pressure in Adults in Rural China: The Healthy Family Program
Key Points: A community- and family-based intervention can reduce systolic blood pressure…
DASH Diet Patterned Groceries Help Reduce Blood Pressure in Black Adults: The GOFRESH Trial
Key Points: The GOFRESH trial, a parallel-group randomized study, was conducted to…
BETTER-BP: Offering Cash Incentives Improves Anti-Hypertensive Medication Adherence, But Not Blood Pressure Control
Key Points: Adherence to antihypertensive medications remains a persistent challenge in clinical…
Oral KCl Supplementation Lowers Sodium Load and Blood Pressure in Hypertension: SSTT Trial
Key Points The See Sodium to Treat (SSTT) Trial tested whether isolated…
A single SC dose of Zilebesiran reduced systolic blood pressure in uncontrolled hypertension: KARDIA-2
Key Points: Zilebesiran is a subcutaneous injectable that targets hepatic angiotensinogen (AGT)…
BrigHTN: Baxdrostat, an aldosterone synthase inhibitor, showed dose-related reductions in blood pressure and safely and effectively lowers blood pressure in patients with resistant hypertension
Key Points In a Phase 2 randomized trial, baxdrostat, a highly potent…
FRESH –First-in-Class Aminopeptidase-A Inhibitor Firibastat Fails in Resistant Hypertension
Key Points Hypertension remains a major public health threat contributing significantly to…
PRECISION –Dual Endothelin Receptor Antagonist Aprocitentan Superior to Placebo in Resistant Hypertension
Key Points Despite the many drug classes available to treat hypertension, the…
The Diuretic Comparison Project (DCP): For hypertensive patients already on hydrochlorothiazide, switching to chlorthalidone does not improve outcomes
Key Points: Thiazide type diuretics are first-line medications for hypertension (HTN); while…
RADIANCE II: Endovascular ultrasound denervation met primary/secondary efficacy BP lowering endpoints at 2 months
Key Points: Endovascular ultrasound denervation (uRDN) is a potentially useful technique in…
Salt substitutes decrease rates of stroke, cardiovascular events, and mortality: results from SSaSS
Key Points: The Salt Substitute and Stroke (SSaSS) study compared the effect…
1.3 Million Patient Study Shows That Even With New Lower Definition for Hypertension, Elevated Systolic and Diastolic Blood Pressure Both Independently Increase Risk of Cardiovascular Events
In a recent original cohort study done by Alexander C. Flint and…
Genetic Epidemiological Study Provides Conflicting Evidence Regarding Protective Effect of Moderate Alcohol Consumption
An article published in the Lancet by Dr. Millwood provided conflicting evidence…
A Systematic Analysis Attributes Eleven Million Deaths in 2017 to Dietary Risk Factors
A systematic analysis by Dr. Ashkan Afshin and the Global Burden of…